Selective interaction of tirapazamine with DNA bases and DNA. A comparison of cyclic voltammetry and electrolysis techniques

Free Radical Research

Volumn 35, Issue 2, 2001, Pages 159-166

  Tocher, J H ^a  

^a UNIVERSITY OF EAST LONDON   (United Kingdom)

Author keywords

Cyclic voltammetry; DNA interaction; Electrosynthesis; Reductive activation; Tirapazamine

Indexed keywords

ADENINE; ANION; CYTOSINE; DNA; DNA BASE; GUANINE; N,N DIMETHYLFORMAMIDE; RADICAL; RIBOSE; THYMINE; TIRAPAZAMINE;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DRUG SELECTIVITY; DRUG TARGETING; ELECTROLYSIS; ELECTRON TRANSPORT; ESCHERICHIA COLI; OXIDATION REDUCTION POTENTIAL;

ESCHERICHIA COLI;

EID: 0034897150     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300701     Document Type: Article

References (17)

1. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Tumors
2. Tirapazamine: A new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer
3. SR4233 9Tirapazamine): A new anti-cancer drug exploiting hypoxia in solid tumors
4. Metabolism of SR4233 by Chinese hamster ovary cells: Basis of selective toxicity
5. Electrochemical studies and DNA damaging effects of the benzotriazine-N-oxides
6. Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes
7. Reaction of the hypoxia-selective antitumour agent tirapazamine with the C1′-radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in damage reactions
8. DNA damaging effects and voltammetric studies of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide, SR4233, as a function of pH
9. Electrochemical studies of tirapazamine: Generation of the one-electron reduction product
10. Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases
11. The reactivity of chloramphenicol reduction products with DNA bases
12. The effect of nitroheterocyclic drugs on DNA: An in vitro model of cytotoxicity
13. Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR4233)
14. Effects of the benzotriazine-di-N-oxide tirapazamine upon DNA
15. DNA damaging effects of benzotriazine-N-oxides
16. Adaptation of human tumor cell lines to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity
17. Bioreductive therapies: An overview of drugs and their mechanisms of action