Amphipathic variable region heavy chain peptides derived from monoclonal human wegener's anti-PR3 antibodies stimulate lymphocytes from patients with wegener's granulomatosis and microscopic polyangiitis

Clinical and Experimental Immunology

Volumn 125, Issue 2, 2001, Pages 323-331

  Peen, E ^a   Malone, C ^a   Myers, C ^a   Williams Jr , R C ^a,c   Peck, A B ^a   Csernok, E ^b   Gross, W L ^b   Staud, R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Amphipathic; T cell epitopes; Wegener's granulomatosis

Indexed keywords

AMINO ACID; ANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; PEPTIDE; PROTEINASE 3 ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOREACTIVITY; MICROSCOPIC POLYANGIITIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION; VASCULITIS; WEGENER GRANULOMATOSIS;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MYELOBLASTIN; PEPTIDES; SERINE ENDOPEPTIDASES; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 0034892237     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01482.x     Document Type: Article

References (37)

1. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis
2. Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
3. Vasculitis affecting the Kidney. Presentation, histopathology and long-term outcome
4. Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
5. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
6. Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells
7. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release
8. Incidence and disease associations of a proteinase 3 -Antineutrophil cytoplasmic antibody idiotype (5/7 Id) whose anti-idiotype inhibits proteinase 3-antineutrophil cytoplasmic antibody antigen binding activity
9. Establishment of the primary amino acid sequence and three dimensional structure of the VII and VL regions of WGH1, a human monoclonal anti-PR3
10. Determination of primary amino acid sequence and unique three dimensional structure of WGH1 a monoclonal human IgM antibody with anti-PR3 specificity
11. Structural analysis of human antibodies to proteinase 3 from patients with Wegener granulomatosis
12. Protein antigenic structures recognized by T cells: Potential applications to vaccine design
13. Prediction of immunodominant helper T-cell antigenic sites from the primary sequence
14. A sequence pattern common to T-cell epitopes
15. Multi-pin peptide synthesis strategy for T-cell determinant analysis
16. A peptide derived from an autoantibody can stimulate T-cells in the (NZW X NZN) f1 mouse model of systemic lupus erythematosus
17. T-cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus
18. An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
19. Anti-neutrophil cytoplasm antibodies in rheumatoid arthritis
20. Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. Characterization and clinical correlations
21. Occurrence of antineutrophil cytoplasmic and antineutrophil (peri) nuclear antibodies in rheumatoid arthritis
22. Incidence, target antigens, and clinical implications of antineutrophil cytoplasmic antibodies in rheumatoid arthritis
23. Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins
24. T-cell antigenic sites tend to be amphipathic structures
25. Molecular features of class II MHC-restricted T-cell recognition of protein and peptide antigens: The importance of amphipathic structures
26. Strong conformational propensities enhance T-cell antigenicity
27. Clinical and immunological follow-up of patients with severe renal disease in Wegener's granulomatosis
28. Cellular immune responses and pathogenesis in c-ANCA positive vasculitis
29. In situ production of TNF-α, IL-1β and IL-2R in ANCA-positive glomerulonephritis
30. Immunopathological studies of polyarteritis nodosa and Wegener's granulomatosis: A report of 43 patients with 51 renal biopsies
31. + T-cells exhibiting an unbalanced Th1 - type T-cell cytokine pattern: Reversal with IL-10
32. T lymphocyte responses to myeloperoxidase, proteinase 3 and proteinase 3 peptides from patients with ANCA-associated systemic vasculitis
33. Targeted T-cell therapy for human leukemia: Cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells
34. Cytotoxic T lymphocytes specific for a non-polymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units
35. Superactivation of an immune response triggered by oligomerized T-cell epitopes
36. Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences
37. Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein