Glucocorticoid-remediable aldosteronism

Endocrinologist

Volumn 11, Issue 4, 2001, Pages 263-268

  Dluhy, Robert G ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; AMILORIDE; AMLODIPINE; BENZTHIAZIDE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; EPLERENONE; FUROSEMIDE; GENE PRODUCT; GLUCOCORTICOID; HYDROCHLOROTHIAZIDE; HYDROCORTISONE; MINERALOCORTICOID; MINERALOCORTICOID ANTAGONIST; NIFEDIPINE; RENIN; SPIRONOLACTONE; STEROID; STEROID 11BETA MONOOXYGENASE;

ALDOSTERONE RELEASE; AUTOSOMAL DOMINANT INHERITANCE; CLINICAL FEATURE; CROSSING OVER; DISEASE SEVERITY; DRUG INDUCED DISEASE; ENZYME ACTIVITY; FAMILY HISTORY; GENE DUPLICATION; GENE EXPRESSION; GENE FUSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HYDROCORTISONE RELEASE; HYPERALDOSTERONISM; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; ONSET AGE; PATHOPHYSIOLOGY; REVIEW; SEQUENCE HOMOLOGY; STROKE;

EID: 0034891982     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019616-200107000-00003     Document Type: Review

References (15)

1. Hypertension, increase aldosterone secretion and low plasma renin activity relieved by dexamethasone
2. Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism
3. Impaired potassium-stimulated aldosterone production: A possible explanation for normokalemic glucocorticoid-remediable aldosteronism
4. Elevated urinary excretion of 18-oxo-cortisol in gluccocorticoid-remediable aldosteronism
5. Glucocorticoid-remediable aldosteronism (GRA) is associated with severe hypertension in early childhood
6. Pediatric hypertension: Clinical perspective
7. Glucocorticoid-remediable aldosteronism in a large kindred: Clinical spectrum and diagnosis using a characteristic biochemical pheno-type
8. Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism
9. A chimeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
10. Hereditary hypertension caused by chimeric gene duplications and ectopic expression of aldosterone synthase
11. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2
12. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme
13. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol
14. Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-remediable aldosteronism
15. A PCR-based method of screening individuals of all ages, from neonates to the elderly, for familial hyperaldosteronism type I