Three thiadiazinone derivatives, EMD 60417, EMD 66430, and EMD 66398, with class III antiarrhythmic activity but different electrophysiologic profiles

Journal of Cardiovascular Pharmacology

Volumn 38, Issue 3, 2001, Pages 438-449

  Himmel, Herbert M ^a   Wettwer, Erich ^a   Lues, Inge ^a,b   Beier, Norbert ^a,b   Jonas, Rochus ^a,b   Ravens, Ursula ^a,c  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MERCK KGAA   (Germany)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Calcium current; Class III antiarrhythmic action; Delayed rectifier current; Guinea pig ventricular myocytes; Human atrial myocytes; Inward rectifier current; Outward current; Selectivity; Sodium current

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 5 [1 (ALPHA ETHYLIMINO 3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDROQUINOLIN 6 YL] 3 METHYL 3,6 DIHYDRO 2H 1,3,4 THIADIAZIN 2 ONE; 5 [1 (ALPHA ETHYLIMINO 3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDROQUINOLIN 6 YL] 6,6 DIMETHYL 3,6 DIHYDRO 2H 1,3,4 THIADIAZIN 2 ONE; 5 [1 (ALPHA ETHYLIMINO 4 METHYLSULFONYLAMINOBENZOYL) 1,2,3,4 TETRAHYDROQUINOLIN 6 YL] 3 METHYL 3,6 DIHYDRO 1H 1,3,4 THIADIAZIN 2 ONE; ALMOKALANT; ANTIARRHYTHMIC AGENT; EMD 59730; EMD 60417; EMD 66398; EMD 66430; QUINIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; ISOLATED HEART; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS; ELECTROPHYSIOLOGY; GUINEA PIGS; HEART; HUMANS; MOLECULAR STRUCTURE; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SODIUM CHANNELS; THIADIAZINES;

EID: 0034891856     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200109000-00012     Document Type: Article

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