Stereoselectivity of actions of the calcium sensitizer [+]-EMD 60263 and its enantiomer [-]-EMD 60264

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 355, Issue 6, 1997, Pages 733-742

  Ravens, Ursula ^a   Flüß, Michael O ^a   Li, Qi ^b   Himmel, Herbert M ^a   Wettwer, Erich ^a   Klockow, Michael ^c   Lues, Inge ^c  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b QUEEN S UNIVERSITY   (Canada)

^c MERCK KGAA   (Germany)

Author keywords

Action potential prolongation; Ca2+ sensitizing action; Delayed rectifier current; Guinea pig cardiac myocytes; I(Kr) block; Positive inotropic effect; Stereoselectivity

Indexed keywords

5 [1 (ALPHA ETHYLIMINO 3,4 DIMETHOXYBENZYL) 1,2,3,4 TETRAHYDRO 6 QUINOLINYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; ANTIARRHYTHMIC AGENT; CALCIUM SENSITIZER; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ENANTIOMER; GUINEA PIG; HEART MUSCLE; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; HUMAN; HUMAN TISSUE; INOTROPISM; NONHUMAN; STEREOCHEMISTRY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ACTION POTENTIALS; ANIMALS; ATRIAL FUNCTION; CALCIUM; ELECTRIC STIMULATION; GUINEA PIGS; HEART RATE; HEART VENTRICLES; HUMANS; MALE; MEMBRANE POTENTIALS; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; STEREOISOMERISM; SWINE; THIADIAZINES;

EID: 0030876271     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005007     Document Type: Article

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