Regression of engineered myeloma cells secreting interferon-γ-inducing factor is mediated by both CD4+/CD8+ T and natural killer cells

Leukemia Research

Volumn 25, Issue 10, 2001, Pages 909-915

  Xiang, Jim ^a   Chen, Zhuang ^a   Huang, Hui ^a   Moyana, Terence ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

IL 18; Myeloma regression; NK cells; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 18;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL TRANSPLANTATION; CELL TYPE; CONTROLLED STUDY; GENE TRANSFER; IMMUNE RESPONSE; IN VITRO STUDY; ISOGRAFT; MOUSE; MYELOMA CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; TH1 CELL; TUMOR CELL LINE; TUMOR REGRESSION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-18; KILLER CELLS, NATURAL; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MULTIPLE MYELOMA; NEOPLASM REGRESSION, SPONTANEOUS; TUMOR CELLS, CULTURED;

EID: 0034891457     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00052-2     Document Type: Article

References (25)

1. Cloning of a new cytokine that induces IFN-γ production by T cells
2. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
3. IFN-γ-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
4. Cloning of cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
5. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells
6. IFN-γ-inducing factor (IGIF) is a costimulatory factor in the activation of Th1, but not Th2 cells and exerts its effect independently of IL-12
7. In vivo antitumor effects of murine interfreon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites
8. IFN-γ inducing factor/IL-18 administration mediates IFN-γ and IL-12 independent antitumor effects
9. Vaccinations with tumor cells genetically engineered to produce different cytokines: effective not superior to a classical adjuvant
10. Characterization of antitumor immunity derived from the inoculation of myeloma cells secreting the fusion protein RM4/IFN-γ
11. Interferon-γ-inducing factor elicits antitumor immunity in association with interferon-γ production
12. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
13. Roles of IL-4 and IFN in stablizing the T helper cell type 1 and 2 phenotype
14. AK-5 tumor-induced modulation of host immune function: upregulation of Th1-type cytokine response mediates early tumor regression
15. Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from type 2 to a type 1 cytokine profile
16. T helper 2-dominant anti-lymphoma immune response is associated with fatal outcome
17. The role of natural killer cells in innate resistance to infection
18. Interlrukin-12: a proinflammatory cytokine with immuno-regulatory functions that bride innate resistance and antigen-specific adaptive immunity
19. Costimulatory signals are required for optimal proliferation of human natural killer cells
20. IL-1β is required fro IL-12 to induce production of IFN-γ by NK cells: a role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens
21. Type I interferons enhance production of IFN-γ by NK cells
22. - cells
23. Comparison of the effects of interleukin-1β, interleukin-1γ and interferon-γ-inducing factor on the production of interferon-γ by natural killer cells
24. IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell proliferation of IL-12 induced IFN-γ
25. Effectiveness of cancer vaccine therapy using cells transduced with the IL-12 gene combined with systemic IL-18 administration