Linker DNA destabilizes condensed chromatin

Biochemistry and Cell Biology

Volumn 79, Issue 3, 2001, Pages 349-363

  Green, G R ^a   Ferlita, R R ^a   Walkenhorst, W F ^a   Poccia, D L ^a  

^a LOYOLA UNIVERSITY   (United States)

Author keywords

Chicken red blood cell; Chromatin condensation; Gel electrophoresis; Histone variants; Linker DNA; Micrococcal nuclease; Nuclei; Nucleosome; Sea urchin sperm; Trypsin

Indexed keywords

BLOOD; DNA; ELECTROPHORESIS; GENES; THERMAL EFFECTS; TURBIDITY;

BLOOD CELL NUCLEI;

BIOCHEMISTRY;

DNA; HISTONE H1; HISTONE H2B; HISTONE H3; HISTONE H4; HISTONE H5; MICROCOCCAL NUCLEASE; PROTAMINE KINASE; TRYPSIN;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CHICKEN; CHROMATIN CONDENSATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; ERYTHROCYTE; EUKARYOTIC CELL; GENE ACTIVATION; IONIC STRENGTH; NONHUMAN; NUCLEOSOME; PEPTIDE MAPPING; PHASE CONTRAST MICROSCOPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEA URCHIN; TURBIDIMETRY;

EID: 0034891141     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o01-115     Document Type: Article

References (99)

1. Histone H2B phosphorylation in mammalian apoptotic cells. An association with DNA fragmentation
2. The structure of histone H1 and its location in chromatin
3. Regulation of the higher-order structure of chromatin by histones H1 and H5
4. Participation of core histone "tails" in the stabilization of the chromatin solenoid
5. Histone phosphorylation in macro- and micronuclei of Tetrahymena thermophila
6. The site of binding of linker histone to the nucleosome does not depend upon the amino termini of core histones
7. Role of histone acetylation in the assembly and modulation of chromatin structures
8. Chromatin conformation and salt-induced compaction: Three-dimensional structural information from cryoelectron microscopy
9. Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin
10. In vivo H2A phosphorylation sites in tobacco, Tetrahymena and yeast
11. Proteases as structural probes for chromatin: The domain structure of histones
12. Only a small fraction of avian erythrocyte histone is involved in ongoing acetylation
13. The mechanisms of pyknosis: Hypercondensation and death
14. Changes in chromatin folding in solution
15. Dinucleosomes show compaction by ionic strength, consistent with bending of linker DNA
16. The core histone N termini function independently of linker histones during chromatin condensation
17. Linker histones stabilize the intrinsic salt-dependent folding of nucleosomal arrays: Mechanistic ramifications for higher-order chromatin folding
18. Increased phosphorylation of histone H1 in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase
19. Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts
20. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
21. Electrostatic mechanism of chromatin folding
22. Analysis of nuclear degradation during lens cell differentiation
23. Regulation and regulatory parameters of histone modifications
24. Programmed nuclear death: Apoptotic-like degradation of specific nuclei in conjugating Tetrahymena
25. Phosphorylation of linker histone H1 regulates gene expression in vivo by creating a charge patch
26. Phosphorylation of linker histone H1 regulates gene expression in vivo by mimicking H1 removal
27. A role for Saccharomyces cerevisiae histone H2A in DNA repair
28. A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD
29. Solenoidal model for superstructure in chromatin
30. Tetrahymena histone H2A. Acetylation in the N-terminal sequence and phosphorylation in the C-terminal sequence
31. Role of the histone "tails" in the folding of oligonucleosomes depleted of histone H1
32. Phosphorylation of sea urchin sperm H1 and H2B histones precedes chromatin decondensation and H1 exchange during pronuclear formation
33. Interaction of sperm histone variants and linker DNA during spermiogenesis in the sea urchin
34. Phosphorylation of sea urchin histone CS H2A
35. Phosphorylation of plant H2A histones
36. A complex pattern of H2A phosphorylation in the mouse testis
37. Phosphorylation weakens DNA binding by peptides containing multiple quot;SPKK" sequences
38. Histone phosphorylation during sea urchin development
39. MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member
40. Histone acetylation in chromatin structure and transcription
41. Irreversible changes occur in chromatin structure upon dissociation of histone H1
42. Structure and function of the core histone N-termini: More than meets the eye
43. Chromatin condensation is not associated with apoptosis
44. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts
45. A stable alpha-helical element in the carboxy-terminal domain of free and chromatin-bound histone H1 from sea urchin sperm
46. Phosphorylation at clustered -Ser-Pro-X-Lys/Arg- motifs in sperm-specific histones H1 and H2B
47. Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs
48. Structure of chromatin in sea urchin embryos, sperm, and adult somatic cells
49. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
50. Rapid dephosphorylation of H1 histones after apoptosis induction
51. Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter
52. On the location of histones H1 and H5 in the chromatin fiber. Studies with immobilized trypsin and chymotrypsin
53. Rapid exchange of histone H1.1 on chromatin in living human cells
54. Proteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development
55. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
56. Generation and characterization of novel antibodies highly selective for phosphorylated linker histone H1 in Tetrahymena and HeLa cells
57. Phosphorylated and dephosphorylated linker histone H1 reside in distinct chromatin domains in Tetrahymena macronuclei
58. The histone tails of the nucleosome
59. Crystal structure of the nucleosome core particle at 2.8 A resolution
60. An estimate of the extent of folding of nucleosomal DNA by laterally asymmetric neutralization of phosphate groups
61. Dynamic binding of histone H1 to chromatin in living cells
62. Phosphorylation of histone H3 correlates with transcriptionally active loci
63. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
64. Remodeling of nucleoproteins during gametogenesis, fertilization and early development
65. Nuclei and chromosomal proteins
66. Packaging and unpackaging the sea urchin sperm genome
67. Remodeling of sperm chromatin following fertilization: Nucleosome repeat length and histone variant transitions in the absence of DNA synthesis
68. Transitions in histone variants during sea urchin spermatogenesis
69. 6DMAP inhibits chromatin decondensation but not sperm histone kinase in sea urchin male pronuclei
70. The amino acid sequence of wheat histone H2A(1). A core histone with a C-terminal extension
71. The primary structure of the histone H2A(2) type from wheat germ. A core histone type with both N-terminal and C-terminal extensions
72. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
73. Megabase chromatin domains involved in DNA double-strand breaks in vivo
74. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
75. Chromatin condensation: Does histone H1 dephosphorylation play a role?
76. DNA bending by small, mobile multivalent cations
77. Stability and reversibility of higher ordered structure of interphase chromatin: Continuity of deoxyribonucleic acid is not required for maintenance of folded structure
78. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
79. Reversible oligonucleosome self-association: Dependence on divalent cations and core histone tail domains
80. The language of covalent histone modifications
81. DNA bending by asymmetric phosphate neutralization
82. The histone database: A comprehensive WWW resource for histones and histone fold-containing proteins
83. Phosphorylation and dephosphorylation of histone V (H5): Controlled condensation of avian erythrocyte chromatin
84. Phosphorylation of linker histone is associated with transcriptional activation in a normally silent nucleus
85. Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin
86. The higher order structure of chromatin and histone H1
87. Relationships between DNA fragmentation, chromatin condensation, and changes in flow cytometry profiles detected during apoptosis
88. What determines the folding of the chromatin fiber?
89. Two-dimensional NMR studies of staphylococcal nuclease. 2. Sequence-specific assignments of carbon-13 and nitrogen-15 signals from the nuclease H124L-thymidine 3′,5′-bisphosphate-Ca2+ ternary complex
90. Structure, dynamics, and function of chromatin in vitro
91. Electrostatic mechanisms of DNA deformation
92. Chromatin disruption and modification
93. Chromatin organization re-viewed
94. Structural repeating units in chromatin. I. Evidence for their general occurrence
95. Direct detection of linker DNA bending in defined length oligomers of chromatin
96. Linker DNA bending induced by the core histones of chromatin
97. Resolution of histones by polyacrylamide gel electrophoresis in presence of nonionic detergents