Measurement of colonic mucosal concentrations of 5-aminosalicylic acid is useful for estimating its therapeutic efficacy in distal ulcerative colitis: Comparison of orally administered mesalamine and sulfasalazine

Inflammatory Bowel Diseases

Volumn 7, Issue 3, 2001, Pages 221-225

  Naganuma, Makoto ^a   Iwao, Yasushi ^b   Ogata, Haruhiko ^a   Inoue, Nagamu ^a   Funakoshi, Shinsuke ^a   Yamamoto, Shojirou ^a   Nakamura, Yuji ^a   Ishii, Hiromasa ^a   Hibi, Toshifumi ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b Keio University   (Japan)

Author keywords

5 Aminosalicylates, mucosal concentration; Aminosalicylates; Ulcerative colitis, distal

Indexed keywords

5 ACETAMIDOSALICYLIC ACID; ENEMA; MESALAZINE; SALAZOSULFAPYRIDINE; SALOZOPYRINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ACTIVITY; DRUG EFFICACY; DRUG TISSUE LEVEL; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; PRIORITY JOURNAL; RECTUM BIOPSY; SIGMOID; SLOW RELEASE FORMULATION; ULCERATIVE COLITIS;

EID: 0034890464     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-200108000-00007     Document Type: Article

References (16)

1. Double-blind comparison of slow-release 5-aminosalicylate and sulfasalazine in remission maintenance in ulcerative colitis
2. A double-blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis
3. Combined therapy with 5-aminosalicylic acid tablets and enemas for maintaining remission in ulcerative colitis: A randomized double-blind study
4. Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis
5. Rectal and colonic mesalazine concentration in ulcerative colitis: Oral versus oral plus topical treatment
6. Determination of sodium azodisalicylate, salazosulphapyridine and their metabolites in serum, urine and faeces by high-performance liquid chromatography
7. 5-aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis
8. Inflammatory bowel disease
9. Intestinal fate of 5-aminosalicylic acid: Regional and systemic kinetic studies in relation to inflammatory bowel disease
10. Concentrations of 5-ASA and Ac-5-ASA in human ileocolonic biopsy homogenates after oral 5-ASA preparations
11. 5-aminosalicylic acid absorption and metabolism in ulcerative colitis patients receiving maintenance sulphasalazine, olsalazine or mesalazine
12. What dose of 5-aminosalicylic acid (mesalamine) in ulcerative colitis?
13. Alternatives to sulfasalazine: Meta-analysis of 5-ASA in the treatment of ulcerative colitis
14. The mode of action of aminosalicylates in inflammatory bowel disease
15. Mucosal aminosalicylate levels correlate with clinical activity in patients with ulcerative colitis
16. A comparison of mesalamine suspension enema and oral sulfasalazine for treatment of active distal ulcerative colitis in adults