A comparison of mesalamine suspension enema and oral sulfasalazine for treatment of active distal ulcerative colitis in adults

American Journal of Gastroenterology

Volumn 91, Issue 7, 1996, Pages 1338-1342

  Kam, Lori ^a   Cohen, Hartley ^b   Dooley, Cornelius ^b   Rubin, Peter ^b   Orchard, John ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ENEMA; MESALAZINE; PREDNISOLONE; SALAZOSULFAPYRIDINE; STEROID;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; MALE; MULTICENTER STUDY; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION; RECTUM HEMORRHAGE; SIGMOIDOSCOPY; SUSPENSION; TABLET; ULCERATIVE COLITIS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AMINOSALICYLIC ACIDS; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLITIS, ULCERATIVE; DOUBLE-BLIND METHOD; ENEMA; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; MALE; MESALAMINE; MIDDLE AGED; REMISSION INDUCTION; SULFASALAZINE; SUSPENSIONS;

EID: 0030054919     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Taffet SL, Das DM. Sulfasalazine: Adverse effects and desensitization. Dig Dis Sci 1983;28:833-41.
2. Lennard-Jones JE, Longmore AJ, Newell AC, et al. An assessment of prednisone, salazopyrin and topical hydrocortisone hemisuccinate used as outpatient treatment of ulcerative colitis. Gut 1960;1:217-22.
3. Baron JH, Connell AM, Lennard-Jones JE, et al. Sulfasalazine and salicylazosulphadimidine in ulcerative colitis. Lancet 1962;1:1094-6.
4. Salvati EP. The treatment of ulcerative colitis. J Med Soc N J 1963; 60:105-8.
5. Dick AP, Grayson MJ, Carpenter RG, et al. Controlled trial of sulfasalazine in the treatment of ulcerative colitis. Gut 1964;5:437-42.
6. Toovey S, Hudson E, Hendry WF, et al. Sulfasalazine and male infertility: Reversibility and possible mechanism. Gut 1981;22:445-51.
7. O'Morain CA, Smethurst P, Dore CJ, Levi AJ. Reversible male infertility due to sulfasalazine: Studies in man and rat. Gut 1984;25: 1078-84.
8. Azad Kahn AK, Piris J, Truelove SC. An experiment to determine the active therapeutic moiety of sulfasalazine. Lancet 1977;29:892-5.
9. Klotz U, Maier K, Fischer C, et al. Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease. N Engl J Med 1980;303:1499-502.
10. Campieri M, Lanfranchi GA, Bazzocchi G, et al. Treatment of ulcerative colitis with high-dose 5-aminosalicylic acid enemas. Lancet 1981;2:270-1.
11. Lanfranchi GA, Campieri M, Brignola C, et al. Treatment of ulcerative colitis patients with high doses of 5-ASA enemas. Gastroenterology 1984;89:A1151 (abstract).
12. Sutherland LR, Martin F, Greer S, et al. 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987;92:1894-8.
13. Guarinon J, Chatzinoff M, Berk T, et al. 5-Aminosalicylic acid enema in refractory distal ulcerative colitis: Long-term results. Am J Gastroenterol 1987;82:732-7.
14. Kam L, Cohen H, Dooley C, et al. A double-blind comparison of mesalamine rectal suspension enema and oral sulfasalazine in the treatment of distal ulcerative colitis. Gastroenterology 1994;99:A707 (abstract).
15. Freidman L, Richter J, Kirkham S, et al. 5-aminosalicylic acid enemas in refractory distal ulcerative colitis: A randomized, controlled trial. Am J Gastroenterol 1986;81:412-8.
16. Hanauer S, Schultz P. Efficacy of 5-ASA enemas for steroid dependent ulcerative colitis. Gastroenterology 1986;90:A1449 (abstract).
17. The Rowasa Study Group. A double-blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis. Gastroenterology 1995;108:A909 (abstract).