Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages

American Journal of Physiology - Renal Physiology

Volumn 281, Issue 2 50-2, 2001, Pages

  Kuncewicz, T ^a   Balakrishnan, P ^a   Snuggs, M B ^a   Kone, B C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Guanosine 5 triphosphatase; protein protein interaction; Inducible nitric oxide synthase; Lipopolysaccharide; Phagocyte

Indexed keywords

CALMODULIN; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOPROTEIN; LIPOPOLYSACCHARIDE; METHIONINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; TRITON X 100; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE OVEREXPRESSION; IMMUNOPRECIPITATION; KIDNEY INJURY; MACROPHAGE ACTIVATION; MOUSE; NEPHRITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING;

EID: 0034890090     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2001.281.2.f326     Document Type: Article

References (49)

1. Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability
2. Analyzing protein-protein interactions using two-hybrid system
3. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
4. Nitric oxide: A physiologic messenger molecule
5. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
6. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
7. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
8. Assembly of the phagocyte NADPH oxidase: Molecular interaction of oxidase proteins
9. Optical methods in renal research
10. phox to the submembranous actin cytoskeleton during oxidase activation
11. Phagocyte NADPH oxidase p67-phox possesses a novel carboxyl terminal binding site for the GTPases Rac2 and Cdc42
12. Studying the platelet cytoskeleton in Triton X-100 lysates
13. Cloning and characterization of murine endothelial constitutive nitric oxide synthase
14. α-MSH inhibits induction of C/EBPβ-DNA binding activity and NOS2 gene transcription in macrophages
15. Rho-GTPases and the actin cytoskeleton
16. Characterization of a microsomal calcium-dependent nitric oxide synthase in activated J774.2 monocyte/macrophages
17. Cytosolic and membrane-bound nitric oxide synthase
18. PIN: An associated protein inhibitor of neuronal nitric oxide synthase
19. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
20. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
21. phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase
22. Nitric oxide in renal health and disease
23. 1-subunit gene in an MTAL cell line
24. 2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemia
25. Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
26. Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite
27. Nitric oxide and macrophage function
28. Three-dimensional imaging by deconvolution microscopy
29. Molecular characterization and localization of three nitric oxide synthase isoforms in rat kidney
30. Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells
31. Nitric oxide synthase is expressed in human macrophages during foreign body inflammation
32. Tyrosine phosphorylation of inducible nitric oxide synthase: Implications for potential post-translational regulation
33. Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo
34. Kalirin inhibition of inducible nitric-oxide synthase
35. An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity
36. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
37. The Cdc42/Rac interactive binding region motif of the Wiskott-Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation
38. Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages
39. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap
40. Structure-function aspects in the nitric oxide synthases
41. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways
42. Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC 12 cells
43. Interaction of PAK with Rac: Determination of a minimum binding domain on PAK
44. Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex
45. Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
46. Identification of a novel Rac1-interacting protein involved in membrane ruffling
47. The epidermal growth factor receptor is associated with actin filaments
48. Vesicle membrane association of nitric oxide synthase in primary mouse macrophages
49. Bacterial infection induces nitric oxide synthase in human neutrophils