Gene suppression by tristetraprolin and release by the p38 pathway

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 2 25-2, 2001, Pages

  Zhu, Wei ^a   Brauchle, Maria A ^b   Di Padova, Franco ^b   Gram, Hermann ^b   New, Liguo ^a   Ono, Koh ^a   Downey, Jocelyn S ^a,c   Han, Jiahuai ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Gene suppression; Inflammation; Mitogen activated protein kinase; TIS11

Indexed keywords

INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; SYNAPTOPHYSIN; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE INDUCTION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; MACROPHAGE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STABILITY;

EID: 0034885141     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.2.l499     Document Type: Article

References (37)

1. Parallel signal processing among mammalian MAPKs
2. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
3. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
4. T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
5. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
6. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
7. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence
8. Activation of p38 in stimulated human neutrophils: Phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK
9. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions
10. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
11. Identification and characterization of a predominant isoform of human MKK3
12. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient
13. Inhibition of p38 mitogenactivated protein kinase by insulin in cultured fetal neurons
14. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
15. A20 zinc finger protein inhibits TNF and IL-1 signaling
16. Characterization of the structure and function of the fourth member of p38 group MAP kinase-p38δ
17. Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection
18. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
19. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
20. Chemotactic peptide N-formyl-Met-Leu-Phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils
21. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilisation of tumor necrosis factor alpha mRNA
22. Interactions of CCCH zinc finger proteins with mRNA
23. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein
24. Identification and characterization of a novel protein kinase involved in the regulation of inflammatory cytokine biosynthesis
25. Mechanism of antigen-driven selection in germinal centres
26. The Drosophila TIS11 homologue encodes a developmentally controlled gene
27. PRAK, a novel protein kinase regulated by the p38 MAP kinase
28. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide
29. Inhibition of interleukin-1 beta production by SKF86002: Evidence of two sites of in vitro activity and of a time and system dependence
30. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
31. Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine
32. Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14
33. A pathogenic role for TNF alpha in the syndrome of cachexia, arthritis and autoimmunity resulting from tristetraprolin (TTP) deficiency
34. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro
35. Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor
36. The pathophysiology of tumor necrosis factors
37. Regulation of TNF expression by multiple mitogen-activated protein kinase pathways