The effects of human mast-cell products and of phenytoin on androgen 5α-reductase expression in human gingival fibroblasts

Archives of Oral Biology

Volumn 46, Issue 9, 2001, Pages 847-855

  Soory, M ^a   Suchak, A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Androgen metabolites; Gingival fibroblasts; Mast cell products; Phenytoin

Indexed keywords

ALCOHOL DERIVATIVE; ANDROGEN; ANDROSTANOLONE; ANDROSTENEDIONE; HISTAMINE; PHENYTOIN; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE; TESTOSTERONE DERIVATIVE;

ADULT; ANDROGEN METABOLISM; ARTICLE; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; FEMALE; FIBROBLAST; GINGIVA OVERGROWTH; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MAST CELL; METABOLITE; PROTEIN EXPRESSION; SCINTISCANNING; SUPERNATANT;

ADULT; ANDROSTENEDIONE; ANTICONVULSANTS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DIHYDROTESTOSTERONE; ENZYME ACTIVATION; FEMALE; FIBROBLASTS; GINGIVA; GINGIVAL OVERGROWTH; HISTAMINE; HUMANS; MALE; MAST CELLS; MIDDLE AGED; PHENYTOIN; STATISTICS, NONPARAMETRIC; TESTOSTERONE 5-ALPHA-REDUCTASE;

CICONIIFORMES;

EID: 0034885125     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(01)00037-1     Document Type: Article

References (25)

1. The effect of interleukin-1β on hyaluronic acid synthesised by adult human gingival fibroblasts in vitro
2. Mast cells and basophils. Their role in initiating and maintaining inflammatory responses
3. Mast cell tryptase stimulates the synthesis of Type 1 collagen in human lung fibroblasts
4. Identification of androgen receptors in normal human osteoblast-like cells
5. Androgens regulate expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in epithelial cell subcultures
6. Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the FCE RI: Role for mast cell derived transforming growth factor-β and tumour necrosis factor-α
7. Human mast cells activate fibroblasts. Tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis
8. Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin
9. The effect of PDGF, TGF-β and IGF in combination on androgen metabolism by fibroblasts
10. The combined effects of TGF-β, IGF and PDGF on 5α-reductase activity on androgen substrates in human gingival tissue
11. Concentration and synthesis of acidic glycosaminoglycans in gingiva of normal and orchidectomised rats injected with testosterone
12. Medication induced gingival overgrowth
13. Effect of phenytoin medication on the metabolism of epidermal growth factor receptor in cultured fibroblasts
14. Polymerase chain reaction analysis of oestrogen and androgen receptor expression in human gingival and periodontal tissue
15. Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys
16. Immunohistochemical localisation of transforming growth factor beta, basic fibroblast growth factor and heparan sulphate glycosaminoglycan in gingival hyperplasia
17. Risk factors for drug-induced gingival overgrowth
18. Androgen metabolism in gingival hyperplasia induced by nifedipine and cyclosporine
19. The use of human gingival fibroblasts in culture for studying the effects of phenytoin on testosterone metabolism
20. Bacterial steroidogenesis by periodontal pathogens and the effect of bacterial enzymes on steroid conversions by human gingival fibroblasts in culture
21. Phenytoin stimulation of 5α-reductase activity in inflamed gingival fibroblasts
22. The effects of epidermal growth factor, interleukin-1 and phenytoin, alone and in combination on C19 steroid conversions in fibroblasts
23. The effect of minocycline on the metabolism of androgens by human oral periosteal fibroblasts and its inhibition by finasteride
24. Concentration of circulating hormones and metabolism of androgens by human gingiva
25. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor