Gene expressions after thrombolytic treatment of middle cerebral artery clot embolism in mice

Stroke

Volumn 32, Issue 8, 2001, Pages 1912-1919

  Hara, Takayuki ^a   Mies, Günter ^a   Hata, Ryuji ^b   Hossmann, Konstantin Alexander ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebral ischemia, focal; Gene expression; Stress genes; Thrombolysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALTEPLASE; HEAT SHOCK PROTEIN 70; MESSENGER RNA; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD CLOTTING; BRAIN EMBOLISM; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE SEVERITY; FIBRINOLYTIC THERAPY; GENE EXPRESSION; IN SITU HYBRIDIZATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPERFUSION INJURY; SILVER IMPREGNATION; STRESS; STROKE;

EID: 0034884626     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.8.1912     Document Type: Article

References (34)

1. Altered gene expression in cerebral ischemia
2. Ischemic cell death in brain neurons
3. Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice
4. Stimulus-transcription coupling in focal cerebral ischemia
5. Combination therapy with neuroproteclants and thrombolytics in acute ischaemic stroke
6. Experimental studies of ischemic brain edema, I: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
7. Reversible middle cerebral artery occlusion without craniectomy in rats
8. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
9. Evolution of brain infarction after transient focal cerebral ischemia in mice
10. Effect of thrombolysis on the dynamics of infarct evolution after clot embolism of middle cerebral artery in mice
11. A reproducible model of thromboembolic stroke in mice
12. Characterization of the murine plasma fibrinolytic system
13. Studies on the specific fibrinolytic effect of human extrinsic (tissue-type) plasminogen activator in human blood and in various animal species in vitro
14. Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat
15. A pictorial representation of endogenous brain ATP by a bioluminescent method
16. A bioluminescence method for the demonstration of regional glucose distribution in brain slices
17. Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining
18. A reproducible model of middle cerebral artery occlusion in mice: Hemodynamic, biochemical, and magnetic resonance imaging
19. Differential expression of heat schock protein 70 gene between the cortex and caudate after transient focal ischemia in rats
20. Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brain
21. The heat schock stress response after brain lesions: Induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition
22. Key of induced tolerance to ischaemia in gerbil hippocampal CA1 is not at transcriptional level of hsp70 gene: In situ hybridization of hsp70 mRNA
23. Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia
24. Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes
25. The heat-shock response: Regulation and function of heat-shock proteins and molecular chaperones
26. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
27. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: Effect on volume of ischemic injury
28. The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat
29. In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia
30. Effects of ischemic tolerance on mRNA levels of IP3R1, beta-actin, and neuron-specific enolase in hippocampal CA1 area of the gerbil brain
31. Expression of neuron-specific enolase in adult rat brain following status epilepticus
32. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage
33. Neuron-specific enolase is a marker of cerebral ischemia and infarct size in rat cerebrospinal fluid
34. Developmental expression of neuron-specific enolase immunoreactivity and cytochrome oxidase activity in neocortical transplants