Comparison of animal models for the evaluation of radiolabeled androgens

Nuclear Medicine and Biology

Volumn 28, Issue 6, 2001, Pages 613-626

  Downer, Joanna B ^a,b   Jones, Lynne A ^b   Engelbach, John A ^b   Lich, Lennis L ^b   Mao, Wang ^c   Carlson, Kathryn E ^c   Katzenellenbogen, John A ^c   Welch, Michael J ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Androgens; Animal models; Ovarian cancer; Positron emission tomography; Sex hormone binding globulin

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; FLUORINE 18; IODINE 124; IODINE 125; SEX HORMONE BINDING GLOBULIN;

ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CLEARANCE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALE; NONHUMAN; OVARY CARCINOMA; RABBIT; RAT; SCID MOUSE; TISSUE DISTRIBUTION; XENOGRAFT;

ANDROGENS; ANIMALS; AUTORADIOGRAPHY; CRICETINAE; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; IODINE RADIOISOTOPES; ISOTOPE LABELING; MALE; MICE; MODELS, ANIMAL; OVARIAN NEOPLASMS; PAPIO; PROSTATIC NEOPLASMS; RABBITS; RATS; RECEPTORS, CELL SURFACE; SEX HORMONE-BINDING GLOBULIN; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034881910     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00229-3     Document Type: Article

References (48)

1. Acute lithium treatment suppresses the proestrus LH surge in mice: Chronic lithium leads to constant diestrus
2. A critical evaluation of the use of androgen receptor assays to predict the androgen responsiveness of prostatic cancer
3. Hormone receptors in human prostate cancer
4. Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons
5. Androgen receptors in ovarian tumors: Correlation with oestrogen and progesterone receptors in an immunohistochemical and semiquantitative image analysis study
6. Hepatic expression of sex hormone-binding globulin associated with the postnatal surge of serum androgen-binding activity in the Djungarian hamster
7. 18F]Fluoropropyl)-N-Nordiprenorphine biodistribution and metabolism
8. Biological effects of sex hormone-binding globulin on androgen-induced proliferation and androgen metabolism in LNCaP prostate cells
9. Steroid-binding proteins in rabbit plasma: Separation of testosterone binding globulin (TeBG) from corticosteroid-binding globulin (CBG), preliminary characterization of TeBG, and changes in TeBG concentration during sexual maturation
10. The ontogeny of biologically active androgen-binding protein in rat plasma, testis, and epididymis
11. Structure-function relationships of rat androgen-binding protein/human sex-hormone binding globulin: The effect of mutagenesis on steroid-binding parameters
12. Heated nitrogen to rapidly evaporate solutions
13. Roles of estrogen and SHBG in prostate physiology
14. Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors
15. Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice
16. Biodistribution, with high uptake by the reproductive tract, of an intraperitoneally infused radiohalogenated steroidal estrogen-receptor ligand
17. Intracellular actions of steroid hormones and their therapeutic value, indicating the potential of radiohalosteroids against ovarian cancer
18. A new human ovarian carcinoma cell line: Establishment and analysis of tumor-associated markers
19. Synthesis and evaluation of 7α-iodo-5α-dihydrotestosterone as a potential radioligand for androgen receptor
20. The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones
21. Human sex hormone-binding globulin expression in transgenic mice
22. Expression and regulation of human sex hormone-binding globulin transgenes in mice during development
23. Role of sex hormone-binding globulin in target uptake of radiolabelled steroids: Investigations in transgenic models
24. Structure, function, and regulation of androgen-binding protein/sex hormone globulin
25. Sex hormone binding globulin and transcortin in human and baboon males
26. 18F production
27. Interaction of sex hormone-binding globulin with plasma membranes from rat epididymis and other tissues
28. Androgen receptor predominance in human ovarian carcinoma
29. Multiple parameter analyses of human ovarian cancer: Morphology, immunohistochemistry, steroid hormone receptors and aromatase
30. 7α-Iodine-125-iodo-5α-dihydrotestosterone: A radiolabeled ligand for the androgen receptor
31. 7α-Iodo and 7α-fluoro steroids as androgen receptor-mediated imaging agents
32. Fluorine-18-labeled androgens: Radiochemical synthesis and tissue distribution studies on six fluorine-substituted androgens, potential imaging agents for prostatic cancer
33. The free hormone hypothesis: A physiologically based mathematical model
34. Tissue uptake of human sex hormone-binding globulin and its influence on ligand kinetics in the adults female rat
35. Action and counter-action of hormones in human ovarian cancer
36. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
37. Simplified method for the quantitative determination of testosterone-estradiol binding globulin activity in human plasma
38. Sex hormone-binding globulin: Binding to cell membranes and generation of a second messenger
39. 124I-labeled monoclonal antibodies
40. Image analysis of androgen receptor immunostaining in metastatic prostate cancer: Heterogeneity as a predictor of response to hormonal therapy
41. 125I]iodo-17β-estradiol in presence of ascites
42. 77Br]-11β-methoxyestradiol-17β, two estrogen receptor-binding radiopharmaceuticals
43. Uptake and retention of androgens by the rat ventral prostate and consideration of their use as site directing agents
44. Effect of the route of administration of the biodistribution of radioiodinated OV-TL 3 F(ab′)2 in experimental ovarian cancer
45. Intraperitoneal xenografts of human epithelial ovarian cancer in nude mice
46. Steroid hormone receptors as targets for diagnostic imaging
47. Inhibition of human epithelial ovarian cancer cell growth in vitro by agonistic and antagonistic analogues of luteinizing hormone-releasing hormone