Pharmacokinetics of oral cyclosporin A when co-administered to enhance the oral absorption of paclitaxel

Anti-Cancer Drugs

Volumn 12, Issue 7, 2001, Pages 591-593

  Malingré, Mirte M ^a,b   Ten Bokkel Huinink, Wim W ^a   Duchin, Ken ^d   Schellens, Jan H M ^a,c   Beijnen, Jos H ^a,b,c  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d Baker Norton Pharmaceuticals Inc   (United States)

Author keywords

Cyclosporin A; Oral administration; Paclitaxel; Pharmacokinetics

Indexed keywords

CIMETIDINE; CLEMASTINE; CYCLOSPORIN A; DEXAMETHASONE; GRANISETRON; PACLITAXEL;

AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG FORMULATION; HUMAN; MAXIMUM ALLOWABLE CONCENTRATION; NAUSEA AND VOMITING; PRIORITY JOURNAL;

ABSORPTION; ADMINISTRATION, ORAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; HUMANS; NEOPLASMS; PACLITAXEL;

EID: 0034881376     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200108000-00005     Document Type: Article

References (13)

1. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
2. Co-administration of cyclosporin enables oral therapy with paclitaxel
3. Co-administration of oral cyclosporin A enables oral therapy with paclitaxel
4. Phase I and pharmacokinetic study of oral paclitaxel
5. Suspected anaphylactic reaction to Cremophor EL
6. Relative performance of specific and non-specific fluorescence polarization immunoassay for cyclosporine in transplant patients
7. Noncompartmental analysis based on statistical moment theory
8. Cyclosporine metabolism in human liver: Identification of a cytochrome P450III gene family as the major cyclosporin-metabolizing enzyme explains interactions of cyclosporin with other drugs
9. Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation
10. Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration
11. Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut
12. Plasma vitamin K1 and PIVKA-II after oral administration of mixed-micellar or cremophor EL-solubilized preparations of vitamin K1 to normal breast-fed newborns
13. Pharmacokinetics and safety of a new solution of vitamin K1(20) in children with cholestasis