Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 2 44-2, 2001, Pages

  Cai, Shi Ying ^a   Wang, Lin ^a   Ballatori, Nazzareno ^b,c   Boyer, James L ^a,c,d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

^d NONE   (United States)

Author keywords

ATP binding cassette transporters; Bile secretion; Cholestasis

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; BILE SALT; CARRIER PROTEIN; COMPLEMENTARY DNA; TAUROCHOLIC ACID;

ANIMAL CELL; ARTICLE; BILE SECRETION; CONTROLLED STUDY; DNA LIBRARY; ELECTRIC FISH; EVOLUTION; GENE MUTATION; GENE SEQUENCE; HUMAN; INTRAHEPATIC BILE DUCT; INTRAHEPATIC CHOLESTASIS; LIVER CELL MEMBRANE; MICHAELIS CONSTANT; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUMP; STRUCTURE ACTIVITY RELATION; VERTEBRATE;

EID: 0034880339     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.2.g316     Document Type: Article

References (18)

1. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump
2. Biliary secretion in elasmobranchs. I. Bile collection and composition
3. Biliary secretion in elasmobranchs. II. Hepatic uptake and biliary excretion of organic anions
4. A rapid and sensitive method of quantitation of microgram quantities of protein utilizing the principle of proteindye binding
5. Duplication and evolution of the P-glycoprotein genes in pig
6. Identification of a sister gene to p-glycoprotein
7. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea)
8. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
9. Molecular cloning and characterization of the murine bile salt export pump
10. Cytoskeletal organization in clusters of isolated polarized skate hepatocytes: Structural and functional evidence for microtubule-dependent transcytosis
11. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
12. Bile alcohol sulfate as a major component in the bile of the small skate (Raja erinacea)
13. Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters
14. A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport
15. ATP-dependent GSH and glutathione S-conjugate transport in skate liver: Role of an Mrp functional homologue
16. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver
17. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis