Therapeutic efficacy of mouse-human chimeric anti-ganglioside GM2 monoclonal antibody against multiple organ micrometastases of human lung cancer in NK cell-depleted scid mice

International Journal of Cancer

Volumn 78, Issue 4, 1998, Pages 480-485

  Hanibuchi, Masaki ^a   Yano, Seiji ^a   Nishioka, Yasuhiko ^a   Yanagawa, Hiroaki ^a   Kawano, Tetsuya ^a   Sone, Saburo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CANCER IMMUNOTHERAPY; COMBINED IMMUNODEFICIENCY; LUNG CANCER; LUNG SMALL CELL CANCER; MALE; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARCINOMA, SMALL CELL; G(M2) GANGLIOSIDE; HUMANS; IMMUNOTHERAPY; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MALE; MICE; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOPLASM TRANSPLANTATION; RECOMBINANT FUSION PROTEINS;

EID: 0031726782     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19981109)78:4<480::AID-IJC14>3.0.CO;2-A     Document Type: Article

References (22)

1. ANDO, I., HOON, D.S., SUZUKI, Y., SAXTON, R.E., GOLUB, S.H. and IRIE, R.F., Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells. Int. J. Cancer, 40, 12-17 (1987).
2. FIDUSR, I. J., Critical factors in the biology of human cancer metastasis: 28th G.H.A. Clowes Memorial Award Lecture. Cancer Res., 50, 6130-6138 (1990).
3. HANIBUCHI, M., YANO, S., NISHIOKA, Y., YANAGAWA, H. and SONE, S., Anti-ganglioside GM2 monoclonal antibody-dependent killing of human lung cancer cells by lymphocytes and monocytes. Jpn. J. Cancer Res., 87, 497-504 (1996).
4. HEIKE, Y., SONE, S., YANO, S., SEIMIYA, H., TSURUO, T. and OGURA, T., M-CSF gene transduction in multidrug-resistant human cancer cells to enhance anti-P-glycoprotein antibody-dependent macrophage-mediated cytotoxicity. Int. J. Cancer, 54, 851-857 (1993).
5. HOON, D.S., ANDO, I., SVILAND, G., TSUCHIDA, T., OKUN, E., MORTON, D.L. and IRIE, R.F., Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells. Int. J. Cancer, 43, 857-862 (1989).
6. ILIOPOULOS, D., ERNST, C., STEPLEWSKI, Z., JAMBROSIC, J.A., RODECK, U., HERLYN, M., CLARK, W.H., JR., KOPROWSKI, H. and HERLYN, D., Inhibition of metastases of a human melanoma. J. nat. Cancer Inst., 81, 440-444 (1989).
7. LEVY, S., HERBERMAN, R., LIPPMAN, M. and D'ANGELO, T., Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. J. clin. Oncol., 5, 348-353 (1987).
8. LI, R., VILLACRESES, N. and LADISCH, S., Human tumor gangliosides inhibit murine immune responses in vivo. Cancer Res., 55, 211-214 (1995).
9. LIVINGSTON, P.O., WONG, G.Y., ADLURI, S., TAO, Y., PADAVAN, M., PARENTE, R., HANLON, C., CALVES, M.J., HELLING, F., RITTER, G., OETTGEN, H.F. and OLD, L.J., Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside. J. clin. Oncol., 12, 1036-1044 (1994).
10. MORRISON, S.L., JOHNSON, M.J., HERZENBERG, L.A. and OI, V.T., Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. nat. Acad. Sci. (Wash.), 81, 6851-6855 (1984).
11. NAKAMURA, K., KOIKE, M., SHITARA, K., KUWANA, Y., KIURAGI, K., IGARASHI, S., HASEGAWA, M. and HANAI, N., Chimeric anti-ganglioside GM2 antibody with antitumor activity. Cancer Res., 54, 1511-1516 (1994).
12. NARASIMHAN, R. and MURRAY, R.K., Neutral glycosphingolipids and gangtiosides of human lung and lung tumours. Biochem. J., 179, 199-211 (1979).
13. NISHINAKA, Y., RAVINDRANATH, M.H. and IRIE, R.F., Development of a human monoclonal antibody to ganglioside GM2 with potential for cancer treatment. Cancer Res., 56, 5666-5671 (1996).
14. PAESMANS, M., SCULIER, J.P., LIBERT, P., BUREAU, G., DABOUIS, G., THIRIAUX, J., MICHEL, J., VAN CUTSEM, O., SERGYSELS, R., MOMMEN, P. and KLASTERSKY, J., Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. J. clin. Oncol., 13, 1221-1230 (1995).
15. RUAN, S. and LLOYD, K.O., Glycosylation pathways in the biosynthesis of gangliosides in melanoma and neuroblastoma cells: relative glycosyltransferase levels determine ganglioside patterns. Cancer Res., 52, 5725-5731 (1992).
16. SALEH, M.N., KHAZAELI, M.B., WHEELER, R.H., ALLEN, L., TILDEN, A.B., GRIZZLE, W., REISFELD, R.A., YU, A.L., GILLIES, S.D. and LOBUGLIO, A.F., A phase I trial of the chimeric anti-GD2 monoclonal antibody ch 14.18 in patients with malignant melanoma. Hum. Antibodies Hybridomas, 3, 19-24 (1992).
17. SCHANTZ, S.P., SHILLITOE, E.J., BROWN, B. and CAMPBELL, B., Natural killer cell activity and head and neck cancer: a clinical assessment. J. nat. Cancer Inst., 77, 869-875 (1986).
18. SHAWLER, D.L., BARTHOLOMEW, R.M., SMITH, L.M. and DILLMAN, R.O., Human immune response to multiple injections of murine monoclonal IgG. J. Immunol., 135, 1530-1535 (1985).
19. 131I-labeled anti-carcinoembryonic antigen monoclonal antibody. Cancer Res., 50 (Suppl. 3), 1039s-1042s (1990).
20. WILLIAMS, L.E., DUDA, R.B., PROFFITT, R.T., BEATTY, B.G., BEATTY, J.D., WONG, J.Y., SHIVELY, J.E. and PAXTON, R.J., Tumor uptake as a function of tumor mass: a mathematic model. J. nucl. Med., 29, 103-109 (1988).
21. YANO, S., NISHIOKA, Y., IZUMI, K., TSURUO, T., TANAKA, T., MIYASAKA, M. and SONE, S., Novel metastasis model of human lung cancer in SCID mice depleted of NK cells. Int. J. Cancer, 67, 211-217 (1996).
22. YANO, S., NISHIOKA, Y., NOKIHARA, H. and SONE, S., Macrophage colony-stimulating factor gene transduction into human lung cancer cells differentially regulates metastasis formations in various organ microenvironments of natural killer cell-depleted SCID mice. Cancer Res., 57, 784-790 (1997).