Study for catecholamine-2′-deoxyguanosine adduct formation under biomimetic conditions using liquid chromatography-electrospray ionization-ion trap mass spectrometry

Journal of Health Science

Volumn 47, Issue 4, 2001, Pages 339-345

  Oe, T ^a   Matsumoto, S ^a   Toyo'oka, T ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

2 deoxyguanosine; Adrenaline; Catecholamine; DNA adduct; Michael addition; Orthoquinone

Indexed keywords

ADRENALIN; CATECHOLAMINE; DEOXYGUANOSINE; MANGANESE OXIDE; OXIDIZING AGENT;

ARTICLE; DIODE; DNA ADDUCT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034879607     PISSN: 13449702     EISSN: None     Source Type: Journal    
DOI: 10.1248/jhs.47.339     Document Type: Article

References (24)

1. Catecholamine synthesis and release. Overview
2. Catecholamine metabolism. From molecular understanding to clinical diagnosis and treatment. Overview
3. The oxidative metabolism of catecholamines in the brain: A review
4. Effects of L-cysteine on the oxidation chemistry of dopamine: New reaction pathways of potential relevance to idiopathic Parkinson's disease
5. Iron- and peroxide-dependent conjugation of dopamine with cysteine: Oxidative routes to the novel brain metabolite 5-S-cysteinyldopamine
6. Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: Possible mechanisms of formation involving reactive oxygen species
7. Molecular characteristics of catechol estrogen quinones in reactions with deoxyribonucleosides
8. Oxidative transformation of 2-hydroxyestrone. Stability and reactivity of 2,3-estrone quinone and its relationship to estrogen carcinogenecity
9. Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators
10. Estrogen-nucleic acid adducts: Reaction of 3,4-estrone-o-quinone radical anion with deoxyribonucleosides
11. Estrogen-nucleic acid adducts: Dissection of the reaction of 3,4-estrone quinone and its radical anion and radical cation with deoxynucleosides and DNA
12. Translesional synthesis on DNA templates containing an estrogen quinone-derived adduct: N2-(2-Hydroxyestron-6-yl)-2′-deoxyguanosine and N6-(2-hydroxyestron-6-yl)-2′-deoxyadenosine
13. Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide
14. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo
15. Prevention of quinone-mediated DNA arylation by antioxidant
16. Synthesis and characterization of polycyclic aromatic hydrocarbone o-quinone depurinating N7-guanine adducts
17. Detection of dopamine-DNA adducts: Potential role in Parkinson's disease
18. Tyrosinase enhances the covalent modification of DNA by dopamine
19. Formation of DNA adducts and oxidative base damage by copper mediated oxidation of dopamine and 6-hydroxydopamine
20. Persistence of N7-(2,3,4-trihydroxybutyl)guanine adducts in the livers of mice and rats exposed to 1,3-butadiene
21. Characterization of endogenous DNA adducts by liquid chromatography/electrospray ionization tandem mass spectrometry
22. Covalent modification of 2′-deoxyguanosine by products of lipid peroxidation
23. Analysis of 1, N2-ethenoguanosine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts
24. Synthesis and biochemical characterization of N1-, N2-, and N7-guanosine adducts of butadiene monoxide