Growth factor-independent proliferation of erythroid cells infected with friend spleen focus-forming virus is protein kinase C dependent but does not require Ras-GTP

Journal of Virology

Volumn 74, Issue 18, 2000, Pages 8444-8451

  Muszynski, K W ^a   Thompson, D ^a   Hanson, C ^a   Lyons, R ^a   Spadaccini, A ^a   Ruscetti, S K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GUANOSINE TRIPHOSPHATE; PROTEIN KINASE C; RAS PROTEIN;

ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; ERYTHROID CELL; FRIEND SPLEEN FOCUS FORMING VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; BLOTTING, WESTERN; CELL DIVISION; ENZYME INHIBITORS; ERYTHROBLASTS; ERYTHROPOIETIN; GRB2 ADAPTOR PROTEIN; GUANOSINE TRIPHOSPHATE; HUMANS; INDOLES; ISOQUINOLINES; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SPLEEN FOCUS-FORMING VIRUSES; STAUROSPORINE; SULFONAMIDES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033857071     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.18.8444-8451.2000     Document Type: Article

References (69)

1. Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the Egf receptor.
2. Protein kinase B (c-akt), phosphatidylinositol 3-kinase, and Stat5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).
3. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages
4. Role of diacylglycerol regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase
5. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes.
6. Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation.
7. Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells
8. Multimeric structure of the membrane erythropoietin receptor of murine erythroleukemia cells (Friend cells)
9. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
10. Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras.
11. Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
12. Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.
13. Multiple cytokines induce the tyrosine phosphorylation of She and its association with Grb2 in hematopoieric cells.
14. Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor.
15. Erythropoietin stimulates the tyrosine phosphorylation of She and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein.
16. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH3T3 cells and in vitro.
17. Minimal Ras-binding domain of Raft can be used as an activation-specific probe for Ras
18. Activation of Raf-1 and mitogen-activated protein kinases by erythropoietin and inositolphosphate-glycan in normal erythroid progenitor cells: involvement of protein kinase C.
19. Signaling by dual specificity kinases.
20. The GRB2/Sem-5 adaptor protein.
21. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin.
22. Inhibition of NIH3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.
23. Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus.
24. Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulation factor induce MGF-Stat5 DNA binding activity.
25. Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases.
26. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
27. Association of the p85 regulatory subunit of phospharidylinositol 3-kinase with an essential erythropoietin receptor subdomain.
28. Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
29. The role of Raf-1 phosphorylation in signal transduction.
30. +.
31. Involvement of phosphatidylinositol 3-kinase in the mediation of erythropoietin-induced activation of p70(s6k).
32. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.
33. Protein kinase C alpha activates RAF 1 by direct phosphorylation
34. Raf-1 activates MAP kinase-kinase.
35. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
36. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.
37. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.
38. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
39. Signaling from TPA to MAP kinase requires protein kinase C, Raf and MEK; reconstitution of the signaling pathway in vitro.
40. Ras target proteins in eukaryotic cells
41. Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor
42. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
43. Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor.
44. Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo.
45. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
46. The complexity of Raf-1 regulation.
47. Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.
48. Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway.
49. Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C.
50. Erythroid cells rendered Epo-independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.
51. Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus.
52. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1.
53. Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells.
54. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
55. Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line.
56. Deregulation of erythropoiesis by the Friend spleen focus-forming virus.
57. SH2/SH3 signaling proteins.
58. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.
59. Erythropoietin increases c-myc mRNA by a protein kinase C-dependent pathway.
60. Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
61. Regulation of very primitive, multipotent, hematopoietic cells by hematopoietin-1.
62. Activation of Raf as a result of recruitment to the plasma membrane.
63. ++ dependent protein kinase.
64. Cell cycle-dependent activation of Ras.
65. Activation of mitogen-activated protein kinase cascade through erythropoietin receptor.
66. Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.
67. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
68. Protein kinase C delta activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.
69. Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways