Isopropyl unoprostone increases the activities of matrix metalloproteinases in cultured monkey ciliary muscle cells

Journal of Glaucoma

Volumn 10, Issue 4, 2001, Pages 271-276

  Kashiwagi, Kenji ^a   Jin, Ming ^a,b   Suzuki, Michihiro ^c   Tanaka, Yuko ^a   Iizuka, Yoko ^a   Tsukahara, Shigeo ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c The Corporation for Production and Research of Laboratory Primates   (Japan)

Author keywords

Ciliary muscle cells; Isopropyl unoprostone; Matrix metalloproteinases; Prostaglandin F2 ; Trabecular meshwork cells

Indexed keywords

ANTIGLAUCOMA AGENT; DRUG METABOLITE; LATANOPROST; MATRIX METALLOPROTEINASE; PROSTAGLANDIN F2 ALPHA DERIVATIVE; UNOPROSTONE ISOPROPYL ESTER;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL METABOLISM; CILIARY MUSCLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; INTRAOCULAR PRESSURE; MONKEY; NONHUMAN; PRIORITY JOURNAL; TRABECULAR MESHWORK;

EID: 0034876620     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00061198-200108000-00005     Document Type: Article

References (28)

1. Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension
2. The potential of prostaglandin derivatives in glaucoma therapy
3. Prostaglandins: A new approach to glaucoma management with a new, intriguing side effect
4. Initial clinical studies with prostaglandins and their analogues
5. Unoprostone (isopropyl unoprostone)
6. Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes
7. Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit
8. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits
9. Prostaglandin action on ciliary smooth muscle extracellular matrix metabolism: Implications for uveoscleral outflow
10. Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro
11. Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-I-isopropylester in the cynomolgus monkey
12. Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells
13. Ocular penetration of UF-021, a new prostaglandin related compound, in the rabbit eye
14. Metabolization of unoprostone isopropyl (UF-021) in isolated pig cornea
15. Metabolites of isopropyl unoprostone as potential ophthalmic solutions to reduce intraocular pressure in pigmented rabbits
16. Calponin distribution in human ciliary muscle and other anterior segment tissues
17. The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells
18. Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol
19. Quantitative zymography: Detection of picogram quantities of gelatinases
20. Arachidonic acid metabolism in human trabecular meshwork cells
21. Monkey trabecular meshwork cells in culture: Growth, morphologic, and biochemical characteristics
22. Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress
23. Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones
24. Families of metalloendopeptidases and their relationships
25. 2 alpha in human ciliary smooth muscle cells
26. Pharmacological characterization of prostaglandin-related ocular hypotensive agents
27. Effects of isopropyl unoprostone on melanogenesis in mouse epidermal melanocytes
28. 2 alpha receptor in rat tissues