Unoprostone (isopropyl unoprostone)

Drugs and Aging

Volumn 9, Issue 3, 1996, Pages 213-218

  Haria, M ^a   Spencer, C M ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; TIMOLOL; UNOPROSTONE ISOPROPYL ESTER;

AQUEOUS HUMOR; AQUEOUS HUMOR OUTFLOW; CHEMICAL STRUCTURE; CLINICAL TRIAL; CONJUNCTIVITIS; DRUG EFFICACY; DRUG RECEPTOR BINDING; EPIPHORA; GLAUCOMA; HUMAN; HYPEREMIA; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; META ANALYSIS; NONHUMAN; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL; REVIEW; TOPICAL DRUG ADMINISTRATION;

EID: 0029762315     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199609030-00007     Document Type: Review

References (30)

1. 1. Y Goh J Kishino 1994 Pharmacological characterization of prosta-glandin-related ocular hypotensive agents Jpn J Ophthalmol 38 3 236 45 1:CAS:528:DyaK2MXitFGisLo%3D Goh Y, Kishino J. Pharmacological characterization of prosta-glandin-related ocular hypotensive agents. Jpn J Ophthalmol 1994; 38(3): 236–45
2. 2. B Resul J Stjernschantz 1993 Structure-activity relationships of prostaglandin analogues as ocular hypotensive agents Curr Opin Ther Pat 3 6 781 95 10.1517/13543776.3.6.781 Resul B, Stjernschantz J. Structure-activity relationships of prostaglandin analogues as ocular hypotensive agents. Curr Opin Ther Pat 1993; 3(6): 781–95
3. 3. R Ueno S Yoshida T Deguchi 1992 The intraocular pressure lowering effects of UF-021, a novel prostaglandin related compound, in animals Nippon Ganka Gakkai Zasshi 96 4 462 8 1621584 1:CAS:528:DyaK2cXjtFKmt74%3D [in Japanese] Ueno R, Yoshida S, Deguchi T, et al. The intraocular pressure lowering effects of UF-021, a novel prostaglandin related compound, in animals [in Japanese]. Nippon Ganka Gakkai Zasshi 1992; 96(4): 462–8
4. 4. M Sakurai M Araie T Oshika 1993 Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit Jpn J Ophthalmol 37 3 252 8 8295362 1:CAS:528:DyaK2cXitlKqs7g%3D Sakurai M, Araie M, Oshika T, et al. Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit. Jpn J Ophthalmol 1993; 37(3): 252–8
5. 5. S Yoshida T Deguchi H Osama 1994 The mechanism of IOP lowering action of Rescula®, a new therapeutic agent for glaucoma and ocular hypertension in various animals — comparison with prostaglandin F 2α Kiso to Rinsho 28 12 3827 38 [in Japanese] Yoshida S, Deguchi T, Osama H, et al. The mechanism of IOP lowering action of Rescula®, a new therapeutic agent for glaucoma and ocular hypertension in various animals — comparison with prostaglandin F 2α [in Japanese]. Kiso to Rinsho 1994; 28(12): 3827–38
6. 6. T Sugiyama S Tokuoka M Nakajima 1992 Changes in rabbit choroidal capillary blood flow and corneal temperature with topically applied UF-021, bunazosin hydrochloride and propranolol hydrochloride J Eye (Atarashii Ganka) 9 8 1430 4 1:CAS:528:DyaK38XmsVGmtrc%3D [in Japanese] Sugiyama T, Tokuoka S, Nakajima M, et al. Changes in rabbit choroidal capillary blood flow and corneal temperature with topically applied UF-021, bunazosin hydrochloride and propranolol hydrochloride [in Japanese]. J Eye (Atarashii Ganka) 1992; 9(8): 1430–4
7. 7. T Ogo 1996 Effect of isopropyl unoprostone on choroidal circulation — changes in choroidal blood flow and intraocular pressure with topical application Folia Ophthalmol Jpn 47 3 268 72 [in Japanese] Ogo T. Effect of isopropyl unoprostone on choroidal circulation — changes in choroidal blood flow and intraocular pressure with topical application [in Japanese]. Folia Ophthalmol Jpn 1996; 47(3): 268–72
8. 8. T Sugiyama I Azuma 1995 Effect of UF-021 on optic nerve head circulation in rabbits Jpn J Ophthalmol 39 2 124 9 8538067 1:CAS:528:DyaK2MXnsFKkurw%3D Sugiyama T, Azuma I. Effect of UF-021 on optic nerve head circulation in rabbits. Jpn J Ophthalmol 1995; 39(2): 124–9
9. 9. H Osama K Kimura T Hirato 1995 General pharmacology of Rescula (isopropyl unoprostone), a novel therapeutic agent for glaucoma and ocular hypertension — comparison of Rescula® with timolol and prostaglandin derivatives Kiso to Rinsho 29 17 4351 68 [in Japanese] Osama H, Kimura K, Hirato T, et al. General pharmacology of Rescula (isopropyl unoprostone), a novel therapeutic agent for glaucoma and ocular hypertension — comparison of Rescula® with timolol and prostaglandin derivatives [in Japanese]. Kiso to Rinsho 1995; 29(17): 4351–68
10. 10. M Sakurai M Araie T Oshika 1991 Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes Jpn J Ophthalmol 35 2 156 65 1779485 1:CAS:528:DyaK3MXmsVyjt7k%3D Sakurai M, Araie M, Oshika T, et al. Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes. Jpn J Ophthalmol 1991; 35(2): 156–65
11. 11. A Komuro N Yokoi Y Matsumoto 1996 Effectiveness of isopropyl unoprostone on corneal epithelial barrier function J Eye (Atarashii Ganka) 13 442 4 [in Japanese] Komuro A, Yokoi N, Matsumoto Y, et al. Effectiveness of isopropyl unoprostone on corneal epithelial barrier function [in Japanese]. J Eye (Atarashii Ganka) 1996; 13: 442–4
12. 12. M Takase M Murao S Koyano 1992 Ocular effects of topical instillation of UF-021 ophthalmic solution in healthy volunteers Nippon Ganka Gakkai Zasshi 96 10 1261 7 1442350 1:STN:280:DyaK3s%2FntFCntw%3D%3D [in Japanese] Takase M, Murao M, Koyano S, et al. Ocular effects of topical instillation of UF-021 ophthalmic solution in healthy volunteers [in Japanese]. Nippon Ganka Gakkai Zasshi 1992; 96(10): 1261–7
13. 13. H Tetsuka H Tsuchisaka K Kin 1992 A mechanism for reducing intraocular pressure in normal volunteers using UF-021, a prostaglandin-related compound Nippon Ganka Gakkai Zasshi 96 4 496 500 1621590 1:STN:280:DyaK38zitFSitg%3D%3D [in Japanese] Tetsuka H, Tsuchisaka H, Kin K, et al. A mechanism for reducing intraocular pressure in normal volunteers using UF-021, a prostaglandin-related compound [in Japanese]. Nippon Ganka Gakkai Zasshi 1992; 96(4): 496–500
14. 14. M Araie M Sakurai Y Suzuki 1993 Effect of UF-021 and timolol on diurnal fluctuation of intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension J Eye (Atarashii Ganka) 10 12 2117 21 [in Japanese] Araie M, Sakurai M, Suzuki Y, et al. Effect of UF-021 and timolol on diurnal fluctuation of intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension [in Japanese]. J Eye (Atarashii Ganka) 1993; 10(12): 2117–21
15. 15. C Watanabe S Matsumoto K Kin 1992 Ocular penetration of UF-021, a new prostaglandin related compound, in the rabbit eye Nippon Ganka Gakkai Zasshi 96 3 335 9 1580216 1:CAS:528:DyaK2cXktVWkur0%3D [in Japanese] Watanabe C, Matsumoto S, Kin K, et al. Ocular penetration of UF-021, a new prostaglandin related compound, in the rabbit eye [in Japanese]. Nippon Ganka Gakkai Zasshi 1992; 96(3): 335–9
16. 16. Ueno Fine Chemicals Industry, Ltd. Isopropyl unoprostone prescribing information. Osaka, Japan, 1995.
17. 17. TS Lesar 1993 Glaucoma JT DiPiro RL Talbert PE Hayes Pharmacotherapy: a pathophysiologic approach 2 Appleton & Lange Norwalk, CT 1363 76 Lesar TS. Glaucoma. In: DiPiro JT, Talbert RL, Hayes PE, et al., editors. Pharmacotherapy: a pathophysiologic approach. 2nd ed. Norwalk, CT: Appleton & Lange, 1993: 1363–76
18. 18. DG Capino HM Leibowitz 1990 Glaucoma: screening, diagnosis, and therapy Hosp Pract 25 73 91 1:STN:280:DyaK3c3msVCktA%3D%3D Capino DG, Leibowitz HM. Glaucoma: screening, diagnosis, and therapy. Hosp Pract 1990; 25: 73–91
19. 19. I Azuma Y Kitazawa H Yamamura 1992 Phase II double-masked dose-determination study of UF-021 ophthalmic solution in primary open-angle glaucoma and ocular hypertension Folia Ophthalmol Jpn 43 12 1425 31 [in Japanese] Azuma I, Kitazawa Y, Yamamura H, et al. Phase II double-masked dose-determination study of UF-021 ophthalmic solution in primary open-angle glaucoma and ocular hypertension [in Japanese]. Folia Ophthalmol Jpn 1992; 43(12): 1425–31
20. 20. I Azuma K Masuda Y Kitazawa 1994 Long-term study of UF-021 (Rescula®) ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension J Eye (Atarashii Ganka) 11 9 1435 44 [in Japanese] Azuma I, Masuda K, Kitazawa Y, et al. Long-term study of UF-021 (Rescula®) ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension [in Japanese]. J Eye (Atarashii Ganka) 1994; 11(9): 1435–44
21. 21. C Fujimori S Yamabayashi M Hosoda 1993 The clinical evaluation of UF-021, a new prostaglandin related compound, in low tension glaucoma patients Nippon Ganka Gakkai Zasshi 97 1231 5 8256677 1:STN:280:DyaK2c%2FnvVymsA%3D%3D [in Japanese] Fujimori C, Yamabayashi S, Hosoda M, et al. The clinical evaluation of UF-021, a new prostaglandin related compound, in low tension glaucoma patients [in Japanese]. Nippon Ganka Gakkai Zasshi 1993 Oct; 97: 1231–5
22. 22. H Okazaki F Shiraga N Matsuo 1994 Clinical evaluation of isopropyl unoprostone (Rescula®) ophthalmic solution in aged glaucoma patients J Eye (Atarashii Ganka) 11 10 1593 8 [in Japanese] Okazaki H, Shiraga F, Matsuo N. Clinical evaluation of isopropyl unoprostone (Rescula®) ophthalmic solution in aged glaucoma patients [in Japanese]. J Eye (Atarashii Ganka) 1994; 11(10): 1593–8
23. 23. T Yamamoto Q Chi Y Kitazawa 1994 Interaction between a prostaglandin F2α derivative, UF-021,and pilocarpine in ocular hypotensive therapy Nippon Ganka Gakkai Zasshi 98 202 5 8109466 1:STN:280:DyaK2c7lt1GhtQ%3D%3D [in Japanese] Yamamoto T, Chi Q, Kitazawa Y. Interaction between a prostaglandin F2α derivative, UF-021,and pilocarpine in ocular hypotensive therapy [in Japanese]. Nippon Ganka Gakkai Zasshi 1994 Feb; 98: 202–5
24. 24. I Azuma K Masuda Y Kitazawa 1993 Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension Jpn J Ophthalmol 37 4 514 25 8145398 1:STN:280:DyaK2c7psVKqtw%3D%3D Azuma I, Masuda K, Kitazawa Y, et al. Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension. Jpn J Ophthalmol 1993; 37(4): 514–25
25. 25. T Nakamatsu S Okinami S Oono 1996 The ocular hypotensive effect of concomitant use of isopropyl unoprostone (Rescula®) and timolol J Eye (Atarashii Ganka) 13 3 439 41 [in Japanese] Nakamatsu T, Okinami S, Oono S. The ocular hypotensive effect of concomitant use of isopropyl unoprostone (Rescula®) and timolol [in Japanese]. J Eye (Atarashii Ganka) 1996; 13(3): 439–41
26. 26. I Azuma 1993 Clinical evaluation of UF-021 ophthalmic solution in glaucoma patients refractory to maximum tolerable therapy Nippon Ganka Gakkai Zasshi 97 232 8 8475836 1:STN:280:DyaK3s3jsFOmtg%3D%3D [in Japanese] Azuma I. Clinical evaluation of UF-021 ophthalmic solution in glaucoma patients refractory to maximum tolerable therapy [in Japanese]. Nippon Ganka Gakkai Zasshi 1993 Feb; 97: 232–8
27. 27. Y Motegi M Araie Y Suzuki 1993 Clinical study of UF-021 ophthalmic solution in refractory glaucoma Folia Ophthalmol Jpn 44 1 12 8 [in Japanese] Motegi Y, Araie M, Suzuki Y, et al. Clinical study of UF-021 ophthalmic solution in refractory glaucoma [in Japanese]. Folia Ophthalmol Jpn 1993; 44(1): 12–8
28. 28. Y Shiose 1993 Clinical study of UF-021 (Rescula®) ophthalmic solution, a novel metabolite-type prostaglandin for the treatment of glaucoma and ocular hypertension J Eye (Atarashii Ganka) 10 10 1761 7 [in Japanese] Shiose Y. Clinical study of UF-021 (Rescula®) ophthalmic solution, a novel metabolite-type prostaglandin for the treatment of glaucoma and ocular hypertension [in Japanese]. J Eye (Atarashii Ganka) 1993; 10(10): 1761–7
29. 29. A Alm 1993 The potential of prostaglandin derivatives in glaucoma therapy Curr Opin Ophthalmol 4 11 44 50 Alm A. The potential of prostaglandin derivatives in glaucoma therapy. Curr Opin Ophthalmol 1993; 4(11): 44–50
30. 30. Exp Opin Ther Patents 1994 4 2 Polar C-l esters of prostaglandins for the treatment of ocular hypertension. Exp Opin Ther Patents 1994; 4(2): 185–6