CD8+ cell changes in psoriasis associated with roxithromycin-induced clinical improvement

European Journal of Dermatology

Volumn 11, Issue 5, 2001, Pages 410-415

  Ohshima, A ^a   Takigawa, M ^a   Tokura, Y ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cutaneous lymphocyte associated antigen; Immunomodulation; Psoriasis; Roxithromycin; Superantigen

Indexed keywords

BACTERIAL ANTIGEN; CD8 ANTIGEN; LYMPHOCYTE ANTIGEN; ROXITHROMYCIN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIBIOTIC THERAPY; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE COUNT; LYMPHOCYTE HOMING; MALE; PSORIASIS; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTI-BACTERIAL AGENTS; ANTIGENS, NEOPLASM; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COUNT; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PSORIASIS; RECEPTORS, ANTIGEN, T-CELL; ROXITHROMYCIN; SEVERITY OF ILLNESS INDEX; SKIN; SUPERANTIGENS; TREATMENT OUTCOME;

EID: 0034875341     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Evolution maturation and regression of lesions of psoriasis
2. T-lymphocyte clones initiated from lesional psoriatic skin release growth factors that induce keratinocyte proliferation
3. Dermal injection of immunocytes induces psoriasis
4. T lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice
5. Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis
6. Tacrolimus (FK 506)-a new therapeutic agent for severe recalcitrant psoriasis
7. The mechanisms of oction of cyclosporin A in the treatment of psoriasis
8. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune but not keratinocyte, pathogenic basis
9. Epidermal T lymphocytes and HLA-DR expression in psoriasis
10. Immunological mechanisms involved in psoriasis
11. A study of the incidence of haemolytic streptococci in the throat in patients with psoriasis vulgaris, with reference to their role in the pathogenesis of this disease
12. Staphylococcus aureus in psoriasis
13. Accessory cell function of keratinocytes for superantigens: Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction
14. Superantigenic staphylococcal exotoxins induce T cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T cell-activating cytokines
15. T cell proliferation to superantigen-releasing Staphylococcus aureus by MHC class II-bearing keratinocytes under protection from bacterial cytolysin
16. Selective expansions of T cells expressing Vβ8 and Vβ13 in skin lesions of patients with chronic cutaneous lupus erythematosus
17. Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis
18. Restricted T cell receptor Vb gene usage in the skin of patients with guttate and chronic plaque psoriasis
19. Hyporesponsiveness of peripheral blood lymphocytes to streptococcal superantigens in patients with guttate Rsoriasis: Evidence for systemic stimulation of T cells with superantigens released from focally infecting Streptococcus pyogenes
20. Bacterial superantigens: Mechanism of T cell activation by the superantigens and their role in the pathogenesis of infectious diseases
21. Superantigens and pseudosuperantigens of gram-positive cocci
22. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites
23. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1
24. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukine-12 production
25. Inhibition of human T lymphocyte activation by macrolide antibiotic, roxithromycin
26. Anti-allergic activity of roxithromycin: Inhibition of interleukine-5 production from mouse T lymphocytes
27. Roxithromycin down-modulates antigen-presenting and interleukine-1b-producing abilities of murine Langerhans cells
28. The macrolide antibiotic roxithromydn suppresses IFN-γ-mediated immunological functions of cultured normal human keratinocytes
29. Inhibitory effect of roxithromycin on the myeloperoxidase activity of peripheral polymorphonuclear leukocytes: Its evaluation in patients with psoriasis and pustulosis palmaris et plantaris
30. Severe psoriasis: Oral therapy with a new retinoid
31. Increased T cell receptor Vbeta2 chain expression in skin haming lymphocytes n psoriasis
32. The staphylococcal enterotoxins and their relatives