Tibolone exerts its protective effect on trabecular bone loss through the estrogen receptor

Journal of Bone and Mineral Research

Volumn 16, Issue 9, 2001, Pages 1651-1657

  Ederveen, A G H ^a   Kloosterboer, H J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Estrogenic; Ovariectomized rat; Progestogen; Tibolone; Trabecular bone loss

Indexed keywords

11BETA [4 (DIMETHYLAMINO)PHENYL] 4',5' DIHYDRO 6BETA METHYLSPIRO[ESTRA 4,9 DIENE 17BETA,2'(3'H) FURAN] 3 ONE; CREATININE; DEOXYPYRIDINOLINE; ESTRADIOL; ESTROGEN RECEPTOR; FLUTAMIDE; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; OSTEOCALCIN; TESTOSTERONE; TIBOLONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; PROTECTION; RAT; TRABECULAR BONE;

AMINO ACIDS; ANABOLIC AGENTS; ANDROGEN ANTAGONISTS; ANIMALS; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; CREATININE; ESTROGEN RECEPTOR MODULATORS; FEMALE; NORPREGNENES; OSTEOCALCIN; OSTEOPOROSIS; OVARIECTOMY; PROGESTINS; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN;

EID: 0034871985     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.9.1651     Document Type: Article

References (24)

1. Metabolic consequences of the menopause. A cross-sectional, longitudinal, and intervention study on 557 normal postmenopausal women
2. Long-term estrogen replacement therapy prevents bone loss and fractures
3. The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats
4. Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats
5. The ovariectomized rat as an animal model for postmenopausal bone loss
6. Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat
7. Skeletal response of ovariectomised rats to low and high doses of 17β-estradiol
8. The effect of ovariectomy and 17β-estradiol on bone histomorphometry in growing rats
9. Pharmacological studies with (7α, 17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD14)
10. Pharmacological profile of Org OD14 in experimental animals. Livial: The current status of research and therapy
11. Tibolone: Prevention of bone loss in late postmenopausal women
12. Effect of tibolone on postmenopausal bone loss
13. Effect of 16 months of treatment with tibolone on bone mass, turnover, and biomechanical quality in mature ovariectomized rats
14. Effect of long-term treatment with Org OD14, its metabolites or 17β-estradiol on bone mass and bone turnover in aged ovariectomized rats
15. The effect of Org OD14 on bone loss in young and old ovariectomized rats
16. Effects of tibolone (Org OD14) treatment for 3 months on ovariectomy-induced osteopenia in 8-month-old rats on a low calcium diet: Preventive testing for 3 months
17. Steroidal pure anti-estrogens
18. The design and use of sex-steroid antagonists
19. Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806
20. Osteocalcin during the reproductive cycle in normal and diabetic rats
21. Tibolone, a steroid with a tissue-specific hormone profile, completely prevents ovariectomy-induced bone loss in sexually mature rats
22. Osteoporosis in men. New insights into aetiology, pathogenesis, prevention and management
23. A nonaromatisable androgen potentiates the effect of an estrogen on the prevention of ovariectomy-induced bone loss in the rat
24. Sex steroids and the regulation of bone volume in the rat