Tibolone: Prevention of bone loss in late postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 7, 1996, Pages 2419-2422

  Bjarnason, Nina Hannover ^a   Bjarnason, Ketil ^a   Haarbo, Jens ^a   Rosenquist, Christian ^b   Christiansen, Claus ^a  

^a CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

^b NORDIC BIOSCIENCE A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

TIBOLONE;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; NORMAL HUMAN; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; ANABOLIC AGENTS; BONE AND BONES; BONE DENSITY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MIDDLE AGED; NORPREGNENES; OSTEOPOROSIS, POSTMENOPAUSAL; PLACEBOS; TIME FACTORS; UTERINE HEMORRHAGE;

EID: 0029974818     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.7.2419     Document Type: Article

References (25)

1. Consensus Development Conference. 1993 Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 94:646-650.
2. Kicovic PM, Cortes-Prieto, Luisi M, Milojevic S, Franchi F. 1982 Placebo-controlled cross-over study of effects of Org OD 14 in menopausal women. Reproduction. 6:81-91.
3. Crona N, Samsioe G, Lindberg U-B, SilfVerstolpe G. 1988 Treatment of climacteric complaints with ORG OD 14: a comparative study with oestradiol valerate and placebo. Maturitas. 9:303-308.
4. Punnonen R, Liukko P, Cortes-Prieto J, et al. 1984 Multicentre study of effects of Org OD 14 on endometrium, vaginal cytology and cervical mucus in postmenopausal and oophorectomized women. Maturitas. 5:281-286.
5. Genazzani AR, Benedek-Jaszmann LJ, Hart DM, et al. 1991 14 and the endometrium. Maturitas. 13:243-251.
6. Lindsay R, Hart DM, Krasewski A. 1980 Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis. Br Med J. 280:1207-1209.
7. Fogelman I, Bessent RG, Smith ML, Hart DM, Lindsay T. 1981 Assessment of synthetic steroid (Org OD 14): effect on skeletal metabolism by 24-h whole-body retention of diphosphonate. Maturitas. 3:265-269.
8. Netelenbos JC, Siregar-Emck MT, Schot LP, van Ginkel FC, Lips P, Leeuwenkamp OR 1991 Short-term effects of Org OD 14 and 17-β-estradiol on bone and lipid metabolism in early postmenopausal women. Maturitas. 13:137-149.
9. Geusens P, Dequeker J, Gielen J, et al. 1991 Non-linear increase of vertebral density by a synthetic steroid (Org OD 14) in established osteopoiosis. Maturitas. 13:155-162.
10. Rymer J, Chapman MG, Fogelman I. 1994 Effect of tibolone on postmenopausal bone loss. Osteoporosis Int. 4:314-319.
11. Metropolitan Life Insurance Tables 1983. Statistical Bulletin. Jan-Jun. pp 3-10.
12. Hansen MA, Hassager C, Overgaard, Marslew, Riis BJ, Christiansen C. 1990 Dual-energy x-ray absorptiometry: a precise method of measuring bone mineral density in the lumbar spine. J Nucl Med. 31:1156-1162.
13. Borg J, Møllgaard A, Riis BJ. 1995 Single x-ray absorptiometry: performance characteristics and comparison to SPA. Osteoporosis Int. 5:377-381.
14. Kleerekoper M, Parfitt AM, Ellis BI. Measurement of vertebral fracture rates in osteoporosis. PTOC of the Copenhagen Int Symp on Osteoporosis. 1984:103-109.
15. Melton LJ, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. 1989 Epidemiology of vertebral fractures in women. Am J Epidemiol. 129:1000-1011.
16. Minne HW, Leidig G, Wuster C, et al. 1988 A newly developed spine deformity index (SDI) to quantitate vertebral crush fractures in patients with osteoporosis. Bone Miner. 3:335-349.
17. International Federation of Clinical Chemistry. 1983 IFCC methods for the measurement of catalytic concentration of enzymes. Part 5. IFCC method for alkaline phosphatase. J Clin Chem Clin Biochem. 21:731-748.
18. Rosenquist C, Bonde M, Fledelius C, Qvist P. 1994 A simple enzyme-linked immunosorbent assay of human osteocalcin. Clin Chem 40:1258-1264.
19. Rosenquist C, Qvist P, Bjarnason N, Christiansen C. 1995 Measurement of a more stable region of osteocalcin in human serum using two monoclonal antibodies in an enzyme-linked immunosorbent assay (ELISA). Clin Chem 41:1439-1445.
20. Podenphant J, Larsen N-E, Christiansen C. 1984 An easy and reliable method for determination of urinary hydroxyproline. Clin Chim Acta 142:145-148.
21. Tietz NV. 1976 Fundamentals of clinical chemistry. Philadelphia: Saunders; 911.
22. Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C. 1995 Evaluation of an immunoassay for quantitation of type 1 collagen degradation products in urine. Clin Chem 40:2022-2025.
23. Luisi M, Franchi F. 1977 Effects of 1.25 mg of Org OD 14 on the hypothalamic-pituitary-ovarian axis function and prolactin/thyrotropin responses to TRH in ovulatory women. Westbury: Organon.
24. van Kuijk C, Berning B, Kuiper JW, et al. 1994 Prevention of early postmenopausal bone loss with Tibolone. J Bone Miner Res. 9(Suppl 1):S325.
25. Rymer J, Fogelman I, Chapman MG. 1994 The incidence of vaginal bleeding with tibolone treatment. Br J Obstet Gynaecol. 101:53-56.