Effect of bufalin on cytotoxicity and growth related gene expression of human hepatoma cell line SMMC 7721

Chinese Journal of Pharmacology and Toxicology

Volumn 15, Issue 4, 2001, Pages 293-296

  Chen, X Y ^a   Hu, W L ^a   Xu, R C ^a   Chen, L ^a   Qian, J ^a  

^a Basic Department   (China)

Author keywords

Apoptosis; Bufalin; Cell line; Cytotoxicity; Gene expression; Necrosis; Proliferating cell nuclear antigen; SMMC 7721

Indexed keywords

BUFADIENOLIDE; BUFALIN; CYCLINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CHINESE MEDICINE; CYTOTOXICITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PROTEIN EXPRESSION;

EID: 0034871766     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Enhancement by bufalin of retinoic acid-induced differentiation of acute promyelocytic leukemia cells in primary culture
2. Tiaml is involved in the regulation of bufalin-induced apoptosis in human leukemia cells
3. Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs
4. + - ATPase inhibition in the early changes in proto-oncogene expression
5. Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells
6. Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells
7. The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells
8. Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinase inhibitors (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors(CKIs)
9. Induction of waf1/cip1 by a p53-independent pathway
10. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
11. Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: Association with the induction of apoptosis in leukemia HL-60 cells
12. Bufalin inhibits endothelial cell proliferation and angiogenesis in vitro