Mutant PLP/DM20 cannot be processed to secrete PLP-related oligodendrocyte differentiation/survival factor

Neurochemical Research

Volumn 26, Issue 6, 2001, Pages 639-645

  Yamada, Masahisa ^a   Jung, Martin ^b   Tetsushi, Kagawa ^a   Ivanova, Anna ^a   Nave, Klaus Armin ^b   Ikenaka, Kazuhiro ^a  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

DM20; Jimpy; Myelin proteolipid protein; Oligodendrocyte; Retrovirus transduction

Indexed keywords

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSDUCTION; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN FOLDING;

3T3 CELLS; ANIMALS; CELL COUNT; CELL DIFFERENTIATION; CELL SURVIVAL; DNA, COMPLEMENTARY; FIBROBLASTS; GENETIC VECTORS; MICE; MICE, INBRED ICR; MUTATION; MYELIN PROTEOLIPID PROTEIN; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; RETROVIRIDAE; TRANSDUCTION, GENETIC;

EID: 0034869755     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010935203196     Document Type: Article

References (34)

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2. DM-20 mRNA is expressed during the embryonic development nervous system of the mouse
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11. Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein
12. Many naturally occurring mutations of myelin proteolipid protein impair its intercellular transport
13. Conservation of topology, but not conformation, of the proteolipid proteins of the myelin sheath
14. Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher Disease
15. Monoclonal Antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): Evidence that PLP misfolding underlies dysmyelination in mutant mice
16. Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain
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18. A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse
19. The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice
20. Glial conditioned medium enables jimpy oligodendrocyte to express properties of normal oligodendrocytes; Production of myelin antigens and membranes
21. Oligodendrocytes of jimpy phenotype can be partially restored by environmental factors in vivo
22. Expression of proteolipid protein gene is directly associated with serection of a factor influencing oligodendrocyte development
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25. msd mice
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27. Improvement of retroviral packaging cell lines by introducing the polyomavirus early region
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