Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans

Journal of Hypertension

Volumn 19, Issue 9, 2001, Pages 1547-1551

  Song, Yanli ^a   Herrera, Victoria L M ^a   Filigheddu, Fabiana ^b   Troffa, Chiara ^b   Lopez, Lyle V ^a   Glorioso, Nicola ^b   Ruiz Opazo, Nelson ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

1, human thiazide sensitive Na,Cl cotransporter; Dahl S rat; Genetics; Hypertension; Na,K,2Clcotransporter; 1 Na,K ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARRIER PROTEIN; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RAT; SEGREGATION ANALYSIS; THIAZIDE SENSITIVE SODIUM CHLORIDE COTRANSPORTER GENE;

EID: 0034867138     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200109000-00005     Document Type: Article

References (14)

1. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotranspotter
2. Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman's syndrome
3. Association of a mutation in thiazide sensitive Na-Cl cotransporter with familial Gitelman's syndrome
4. Linkage of Gitelman syndrome to the thiazidesensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families
5. Novel mutations in the thiazide-sensitive NaCl cotransporter gene in patients with Gitelman syndrome with predominant localization to the C-terminal domain
6. Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
7. Thiazide diuretics in hypertension
8. HSD rats
9. Interaction of α1 Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension
10. Localization of bumetanide- and thiazide-sensitive Na,K,Cl-cotransporters along the rat nephron
11. HSD rat
12. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral Na,K,2Cl cotransporter family expressed in kidney