The effects of isoflurane on acetylcholine receptor channels: 3. Effects of conservative polar-to-nonpolar mutations within the channel pore

Molecular Pharmacology

Volumn 60, Issue 3, 2001, Pages 584-594

  Wenningmann, Ingobert ^a   Barann, Martin ^a   Vidal, Ana Maria ^b   Dilger, James P ^b,c  

^a UNIVERSITY OF BONN   (Germany)

^b STONY BROOK UNIVERSITY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; DECAMETHONIUM; ISOFLURANE;

AMINO ACID SEQUENCE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYDROPHOBICITY; KIDNEY CELL; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; SITE DIRECTED MUTAGENESIS;

ANESTHETICS, INHALATION; ANIMALS; CELLS, CULTURED; DECAMETHONIUM COMPOUNDS; ELECTROPHYSIOLOGY; HUMANS; ISOFLURANE; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; NEUROMUSCULAR DEPOLARIZING AGENTS; PERFUSION; RECEPTORS, CHOLINERGIC; TRANSFECTION;

EID: 0034866470     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
2. 3 receptors by propofol: Equilibrium and kinetic measurements
3. Mutations at 10′ in the channel pore alter the interaction of isoflurane with nicotinic ACh receptor channels in an unexpected way (Abstract)
4. Interactions of general anesthetics within the pore of an ion channel
5. Desensitization of embryonic nicotinic acetylcholine receptors expressed in Xenopus oocytes
6. An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor
7. A distinct contribution of the δ subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment
8. On the stochastic properties of bursts of single ion channel openings and of clusters of bursts
9. Mechanisms of barbiturate inhibition of acetylcholine receptor channels
10. Direct measurement of the concentration- and time-dependent open probability of the nicotinic acetylcholine receptor channel
11. Effects of isoflurane on acetylcholine receptor channels. 1. Single-channel currents
12. Effects of isoflurane on acetylcholine receptor channels. 2. Currents elicited by rapid perfusion of acetylcholine
13. 3H-1 cells
14. Cooperative interactions between general anesthetics and QX-222 within the pore of the acetylcholine receptor ion channel
15. The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
16. Tables of physical and pharmacological properties of anesthetics
17. Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore
18. A discrete site for general anesthetics on a postsynaptic receptor
19. Which molecular targets are most relevant to general anaesthesia?
20. Asymmetric and independent contribution of the second transmembrane segment 12′ residues to diliganded gating of acetylcholine receptor channels. A single-channel study with choline as the agonist
21. Improved patch-clamp techniques for high-resolution current recording from cells and cell free membrane patches
22. Volume changes on protein folding
23. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
24. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
25. Decamethonium is a partial agonist at the nicotinic acetylcholine receptor
26. Opening rate of acetylcholine receptor channels
27. Effects of alcohols and volatile anesthetics on the activation of nicotinic acetylcholine receptor channels
28. The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine
29. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
30. Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes
31. Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor
32. Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant
33. Molecular dissection of subunit interfaces in the acetylcholine receptor - Identification of residues that determine curare selectivity
34. Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by low concentrations of agonist
35. Acetylcholine receptor channel imaged in the open state
36. Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium