Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups

Pharmacology Biochemistry and Behavior

Volumn 69, Issue 3-4, 2001, Pages 527-533

  Hennessy, Michael B ^a   Pitstick, Lisa ^a   O'Leary, Shonagh ^a   Maken, Deborah S ^a   Farré, Antonio J ^b  

^a WRIGHT STATE UNIVERSITY   (United States)

^b Laboratorios Dr Esteve SA   (Spain)

Author keywords

Antidepressant; Cortisol; Guinea pigs; Isolation; Vocalizations

Indexed keywords

5 [A [2 (DIMETHYLAMINO)ETHOXY] 2 THIENYLMETHYL] 1 METHYL 1H PYRAZOLE CITRATE; ANTIDEPRESSANT AGENT; E 6006; E 6039; E 6101; E 6102; HYDROCORTISONE; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENANTIOMER; FEMALE; GUINEA PIG; HYDROCORTISONE BLOOD LEVEL; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; SOCIAL ISOLATION; VOCALIZATION;

ANIMALS; ANIMALS, NEWBORN; ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HYDROCORTISONE; MALE; MOTOR ACTIVITY; PREGNANCY; PYRAZOLES; SOCIAL ISOLATION; VOCALIZATION, ANIMAL;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034865009     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(01)00571-8     Document Type: Article

References (40)

1. 1 receptors by use of the non-peptide antagonist CP-96,345
2. Guinea-pig vocalizations: Their structure, causation and function
3. Stress, antidepressant drugs, and the locus coeruleus
4. Increased plasma catecholamines and locomotor activity induced by centrally administered Substance P in guinea-pigs
5. Substance P stimulates arginine vasopressin and inhibits adrenocorticotropin release in vivo in the rat
6. Endogenous Substance P inhibits the expression of corticotropin-releasing hormone during a chronic inflammatory stress
7. Stimulation of ACTH/cortisol by intravenously infused Substance P in normal men: Inhibition by sodium valproate
8. Corticosterone "basal levels" and response to ether anesthesia in rats on a water deprivation regimen
9. Feedback regulation of adrenocorticotropin secretion in "basal" and "stress" conditions: Acute and chronic effects of intrahypothalamic implants
10. Noradrenergic and serotonergic abnormalities in depression: Stress-induced dysfunction?
11. New tables for multiple comparisons with a control
12. Pharmacological profile of E-6006 citrate, a novel potential antidepressant
13. Species differences in affinities of non-peptide antagonists for substance P receptors
14. Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress (Part 2)
15. Response to maternal separation in infant guinea pigs exposed to intrapartum meperidine
16. Monoamine activity in anterior hypothalamus of guinea pigs separated from their mothers
17. Factors influencing cortisol and behavioral responses to maternal separation in guinea pigs
18. Hormonal and behavioral attachment responses in infant guinea pigs
19. Peripherally administered CRH suppresses the vocalizations of isolated guinea pig pup
20. The influence of maternal separation on plasma concentrations of ACTH, epinephrine, and norepinephrine in guinea pig pups
21. Effects of centrally administered corticotropin-releasing factor (CRF) and α-helical CRF on the vocalizations of isolated guinea pig pups
22. Effects of peripherally administered corticotropin-releasing factor (CRF) and a CRF antagonist: Does peripheral CRF activity mediate behavior of guinea pig pups during isolation?
23. Effects of morphine and naloxone on separation distress and approach attachment: Evidence for opiate mediation of social affect
24. Ascending endorphin inhibition of distress vocalization
25. Substance P is involved in terminating the hypothalamo-pituitary-adrenal axis response to acute stress through centrally located neurokinin-1 receptors
26. The reaction to separation in infant monkeys: Anaclitic depression and conservation withdrawal
27. Distinct mechanism for antidepressant activity by blockade of central Substance P receptors
28. The possible role of endogenous Substance P in the modulation of the response of rat pituitary-adrenal axis to stresses
29. 3H] SP as the radioligand
30. Peripheral administration of a corticotropin-releasing factor antagonist increases the vocalizing and locomotor activity of isolated guinea pig pups
31. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor
32. Social separation in monkeys
33. Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs
34. Attachment and separation distress in the infant guinea pig
35. Effects of imipramine on infant guinea pig distress vocalizations
36. Social attachment of the infant guinea pig to its parents in a two-choice situation
37. Psychoneuroimmunologic factors in neoplasia: Studies in animals
38. Non-specific inhibition of dopamine receptor agonist-induced behaviour by the tachykinin NK1 receptor antagonist CP-99,994 in guinea pigs
39. Studies on the reproductive activities of the guinea pig: II. The role of hunger in filial behavior
40. The rising sun shines on substance P and related peptides