Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene

Genes to Cells

Volumn 6, Issue 8, 2001, Pages 689-697

  Göllner, Heike ^a   Bouwman, Peter ^b   Mangold, Monika ^a   Karis, Alar ^c   Braun, Harald ^a   Rohner, Iris ^a   Del Rey, Adriana ^a   Besedovsky, Hugo Oskar ^a   Meinhardt, Andreas ^a   Van Den Broek, Marion ^b   Cutforth, Tyler ^d   Grosveld, Frank ^b   Philipsen, Sjaak ^b   Suske, Guntram ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c UNIVERSITY OF TARTU   (Estonia)

^d New York Presbyterian Hospital Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR; PHEROMONE; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CONTROLLED STUDY; EXON; FEMALE; GENDER; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE STRUCTURE; GENE TARGETING; GROWTH RETARDATION; HOMOZYGOSITY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; ORGAN SIZE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MOTIF; SEXUAL MATURATION; SPERMATOGENESIS; SPLEEN SIZE; SURVIVAL; THYMUS; UTERUS; VOMERONASAL ORGAN;

ALLELES; ANIMALS; CELL LINE; CHROMOSOME MAPPING; CLONING, MOLECULAR; DNA; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE TARGETING; GROWTH; GROWTH DISORDERS; HOMOZYGOTE; MALE; MICE; MICE, KNOCKOUT; MUTATION; REPRODUCTION; SEXUAL MATURATION; SP4 TRANSCRIPTION FACTOR; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS; ZINC FINGERS;

ANIMALIA;

EID: 0034859517     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2001.00455.x     Document Type: Article

References (26)

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2. Thymus involvement in female sexual maturation
3. Transcription factor Sp3 is essential for post-natal survival and late tooth development
4. Combinatorial action of HNF3 and Sp family transcription factors in the activation of the rabbit uteroglobin/CC10 promoter
5. Unraveling chemosensory diversity
6. An inhibitor domain in Sp3 regulates its glutamine-rich activation domains
7. Tissue-specific in vitro transcription from the mouse albumin promoter
8. Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3
9. Cloning by recognition site screening of two novel GT box binding proteins: A family of Sp1 related genes
10. Sp1-mediated transcriptional activation is repressed by Sp3
11. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury
12. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
13. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene
14. Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15
15. Human Sp3 transcriptional regulator gene (SP3) maps to chromosome 2q31
16. Transcription factor Sp1 is essential for early development but dispensable for cell growth and differentiation
17. A multigene family encoding a diverse array of putative pheromone receptors in mammals
18. Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
19. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
20. A tale of three fingers: The family of mammalian Sp/XKLF transcription factors
21. Assignment of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization
22. Characterization and promoter analysis of the mouse gene for transcription factor Sp4
23. Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility
24. The Sp-family of transcription factors
25. The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression patten during mouse embryogenesis
26. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-able proto-oncogene