Activation of chondrogenesis in response to injury in normal and transgenic mice with cartilage collagen mutations

Osteoarthritis and Cartilage

Volumn 9, Issue SUPPL. A, 2001, Pages

  Uusitalo, H ^a   Salminen, H ^a   Vuorio, E ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Bone; Cartilage; Collagen; Fracture; SOX9; Transgenic mice

Indexed keywords

COLLAGEN; COLLAGEN FIBRIL; COLLAGEN TYPE 2; COLLAGEN TYPE 9; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ADENOVIRUS; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; BONE DEFECT; CALLUS; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL NUCLEUS; CHONDROGENESIS; CHONDROPATHY; CONTROLLED STUDY; DISEASE MODEL; FRACTURE FIXATION; FRACTURE HEALING; GENE MUTATION; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; METAPHYSIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TISSUE REPAIR; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; COLLAGEN; DISEASE MODELS, ANIMAL; FRACTURE HEALING; HIGH MOBILITY GROUP PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; OSTEOARTHRITIS; REGENERATION; TRANSCRIPTION FACTORS;

EID: 0034854778     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Evidence for insufficient chondrocytic differentiation during repair of full-thickness defects of articular cartilage
2. Articular cartilage repair
3. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage
4. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
5. Gene expression during bone repair
6. Regulation of extracellular matrix genes during fracture healing in mice
7. Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice
8. Toward understanding SOX9 function in chondrocyte differentiation
9. Collagens synthesized by healing fractures
10. Expression of cathepsins B, H, K, L and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus
11. Type X collagen synthesis during endochondral ossification in fracture repair
12. In situ localization of collagen production by chondrocytes and osteoblasts in fracture callus
13. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
14. Role of growth factors and cartilage repair
15. SOX9 is a potent activator of the chondrocyte-specific enhancer of the proa1(II) collagen gene
16. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
17. Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer
18. Sox9 is required for cartilage formation
19. Regulation and role of Sox9 in cartilage formation
20. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
21. Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation
22. Bone-healing patterns affected by loading, fracture fragment stability, fracture type, and fracture site compression
23. Production of cartilage collagens during metaphyseal bone healing in the mouse
24. A metaphyseal defect model of the femur for the study of murine bone healing
25. Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of proa1(II) collagen chain
26. Transgenic mice as models for cartilage and eye diseases
27. Type X collagen, a natural component of mouse articular cartilage- Association with growth, aging, and osteoarthritis
28. Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene
29. Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in transgenic mouse model for osteoarthritis
30. Alternative splice form of type II procollagen mRNA (IIA) is predominant in skeletal precursors and non-cartilaginous tissues during early mouse development
31. Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis
32. Induction of periosteal callus formation by bone morphogenetic protein-2 employing adenovirus-mediated gene delivery
33. A new long form of Sox5 (L-Sox5) and Sox6 and Sox9 are co-expressed in chondrogenesis and cooperatively activate the type II collagen gene