Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis

Arthritis and Rheumatism

Volumn 43, Issue 8, 2000, Pages 1742-1748

  Salminen, Heli ^a   Perälä, Merja ^b   Lorenzo, Pilar ^c   Saxne, Tore ^a   Heinegård, Dick ^d   Säämänen, Anna Marja ^a   Vuorio, Eero ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c Lund University ^*

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE 2; GLYCOPROTEIN; MESSENGER RNA; RNA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE MUTATION; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSTEOARTHRITIS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; CARTILAGE, ARTICULAR; COLLAGEN; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; KNEE JOINT; MALE; MICE; MICE, TRANSGENIC; MUTATION; OSTEOARTHRITIS; RNA, MESSENGER; UP-REGULATION;

EID: 0033889620     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200008)43:8<1742::AID-ANR10>3.0.CO;2-U     Document Type: Article

References (39)

1. The biology of osteoarthritis
2. Structure and biology of cartilage and bone matrix noncollagenous macromolecules
3. Cartilage specific collagens, in articular cartilage and osteoarthritis
4. Transgenic mice as models for cartilage and eye diseases
5. Unraveling the molecular genetics of osteoarthrosis
6. Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen
7. Cartilage matrix protein: An acidic oligomeric protein (COMP) detected only in cartilage
8. Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon
9. The distribution of cartilage oligomeric matrix protein (COMP) in tendon and its variation with tendon site, age and load
10. Electron microscopy of native cartilage oligomeric matrix protein purified from the swarm rat chondrosarcoma reveals a five-armed structure
11. COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins
12. Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development
13. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis
14. Cartilage and bone metabolism in rheumatoid arthritis: Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism
15. Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint
16. Identification and characterization of a novel cartilage gene product CILP, which is an early indicator of osteoarthritis [thesis]
17. Changes in serum cartilage marker levels indicate altered cartilage metabolism in families with the osteoarthritis-related type II collagen gene COL2A1 mutation
18. Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint
19. Cartilage metabolism in the injured and uninjured knee of the same patient
20. Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts
21. Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes
22. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation
23. Chondrodysplasia in transgenic mice harboring a 15 amino acid deletion in triple helical domain of proα1(II) collagen chain
24. Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in the type II collagen gene
25. An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1)
26. Characterization of human and mouse cartilage oligomeric matrix protein
27. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
28. Cartilage oligomeric matrix protein: A novel marker of cartilage turnover detectable in synovial fluid and blood
29. Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis
30. Type X collagen, a natural component of mouse articular cartilage: Association with growth, aging, and osteoarthritis
31. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene
32. Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia
33. Multiple epiphyseal dysplasia, ribbing type: A novel point mutation in the COMP gene in a South African family
34. Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein
35. Physiological and pathological secretion of cartilage oligomeric matrix protein by cells in culture
36. A mutation in the gene encoding the α2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (MED2)
37. D-periodic distribution of collagen type IX along cartilage fibrils
38. Collagen type IX from human cartilage: A structural profile of intermolecular cross-linking sites
39. Mice lacking α1(IX) collagen develop noninflammatory degenerative joint disease