Interaction of new PNA-based molecules with TAR RNA of HIV-1: Molecular modelling and biological evaluation

Journal of Molecular Graphics and Modelling

Volumn 19, Issue 6, 2001, Pages

  Terreux, R ^a   Pairot, S ^b   Cabrol Bass, D ^a,b   Patino, N ^b   Condom, R ^b  

^a Lab Chim des Arom Synth Intrac   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PROTEINS; RNA;

REPLICATIONS;

MOLECULAR GRAPHICS;

CELL PROTEIN; NUCLEOSIDE ANALOG; PEPTIDE NUCLEIC ACID; PEPTIDIC NUCLEIC ANALOG; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DNA TRANSCRIPTION; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA SEQUENCE; TRANSACTIVATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034845325     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(01)00095-X     Document Type: Article

References (22)

1. Development of resistance of human immunodifiency virus (HIV) to anti-HIV agent: How to prevent the problem?
2. HIV-1 Tat protein promotes formation of more-processive elongation complexes
3. Regulation of the HIV gene expression by RNA-protein interactions
4. Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge
5. High affinity binding of TAR RNA by the human immunodeficiency virus type-1 Tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region
6. Mechanism of action of regulatory proteins encoded by complex retroviruses
7. Specific binding of arginine to TAR RNA
8. Dissection of the proposed base triple in human immunodeficiency virus TAR RNA indicates the importance of the Hoogsteen interaction
9. Conformation of the TAR-RNA-arginine complex by NMR spectroscopy
10. Role of RNA structure in arginine recognition of TAR RNA
11. Circular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine
12. Sequence selective recognition by atomes displacement with a thymine substituted polyamide
13. Peptide Nucleic Acids (PNA) oligonucleotide analogues with an achiral peptidic backbone
14. A second generation force field for the simulation of proteins, nucleic acids, and organic molecules
15. Algorithms for macromolecular dynamics and constraint dynamics
16. Molecular dynamics with coupling to an external bath
17. Modeling of the interaction between new ethidium derivatives and TAR RNA of HIV-1
18. Liquid phase synthesis of peptide nucleic acid (or polyamide nucleic acid) dimers
19. Synthesis, deprotection, analysis and purification of RNA and ribozymes
20. Variable selection method improves the prediction of protein secondary structure from circular dichroism spectra