Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma

Leukemia and Lymphoma

Volumn 42, Issue 5, 2001, Pages 1107-1109

  Hofmann, W K ^a   Tsukasaki, K ^a   Takeuchi, N ^a   Takeuchi, S ^a   Koeffler, H P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adult T cell leukemia lymphoma; Cell cycle control genes; Methylation; Methylation specific polymerase chain reaction; Retinoblastoma protein

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; DNA; PROTEIN P15; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ADULT; ARTICLE; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; GENE CONTROL; GENE INACTIVATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INCIDENCE; LEUKEMIA CELL; LYMPHOMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATOR GENE; T CELL LEUKEMIA; T CELL LYMPHOMA;

EID: 0034839329     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190109097731     Document Type: Article

References (12)

1. Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia
2. Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)
3. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies
4. Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: Frequent clonal change at crisis from indolent disease
5. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
6. Deletion of the p16INK4A gene in ex vivo acute adult T cell lymphoma/leukemia cells and methylation of the p16INK4A promoter in HTLV type I-infected T cell lines
7. Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia
8. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
9. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
10. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
11. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
12. HTLV-I Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4