Proliferation, not apoptosis, alters epithelial cell migration in small intestine of CFTR null mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 3 44-3, 2001, Pages

  Gallagher, A M ^a   Gottlieb, R A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Animal model; Cystic fibrosis transmembrane conductance regulator; Pathophysiology

Indexed keywords

CYCLINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYSTIC FIBROSIS; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; INTESTINE VILLUS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0034838017     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.3.g681     Document Type: Article

References (27)

1. +
2. Functional activation of the cystic fibrosis trafficking mutant ΔF508-CFTR by overexpression
3. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis
4. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature sensitive
5. High intracellular pH is lowered by retrovirus-mediated CFTR gene transfer
6. Altered sulfate transport via anion exchange in CFPAC is corrected by retrovirus-mediated CFTR gene transfer
7. A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo
8. Intracellular pH of mitogen-stimulated lymphocytes
9. Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: Possible relevance to cystic fibrosis
10. Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis
11. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
12. Determination of proliferative activity in nasal polyps
13. YO-PRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability
14. Toward an animal model of cystic fibrosis: Targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells
15. Cell proliferation in bronchial epithelium and submucosal glands of cystic fibrosis patients
16. Characterization of inflammatory reaction in upper airways of cystic fibrosis patients
17. Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification
18. Age changes in stem cells of murine small intestinal crypts
19. Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence
20. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer
21. Epithelial cell growth differentiation. II. Intestinal apoptosis
22. Early signals in the mitogenic response
23. Biosynthetic and growth abnormalities are associated with high-level expression of CFTR in heterologous cells
24. The fate of effete epithelial cells at the villus tips of the human small intestine
25. Intestinal inflammation in cystic fibrosis
26. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator
27. 2+ and pH: Putative signals for the control of cell growth