Arterial and venous pharmacokinetics of intravenous heroin in subjects who are addicted to narcotics

Clinical Pharmacology and Therapeutics

Volumn 70, Issue 3, 2001, Pages 237-246

  Rentsch, Katharina M ^a   Kullak Ublick, Gerd A ^a   Reichel, Christoph ^a   Meier, Peter J ^a   Fattinger, Karin ^a,b  

^a University Hospital ^*  (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; DIAMORPHINE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 ACETATE; MORPHINE 6 GLUCURONIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NARCOTIC DEPENDENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALGESICS, OPIOID; AREA UNDER CURVE; BIOTRANSFORMATION; DEALKYLATION; FEMALE; HALF-LIFE; HEROIN; HEROIN DEPENDENCE; HUMANS; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; MALE; REGIONAL BLOOD FLOW;

EID: 0034828681     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2001.117981     Document Type: Article

References (24)

1. The discovery of heroin
2. Analgesic and mood effects of heroin and morphine in cancer patients with postoperative pain
3. The pharmacokinetics of heroin in patients with chronic pain
4. Adolescent heroin use: A review
5. Acute heroin overdose
6. Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics
7. Arterial and venous cocaine plasma concentrations in humans: Relationship to route of administration, cardiovascular effects and subjective effects
8. Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine
9. Determination of morphine and its 3- and 6-glucuronides, codeine, codeine-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography atmospheric pressure chemical ionization mass spectrometry
10. A nonparametric subject-specific population method for deconvolution. I. Description, internal validation and real data examples
11. A nonparametric subject-specific population method for deconvolution. II. External validation
12. Influence of arteriovenous sampling on remifentanil pharmacokinetics and pharmacodynamics
13. Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase
14. Kinetics of heroin deacetylation in aqueous alkaline solution and in human serum and whole blood
15. The pharmacologic effects of heroin in relationship to its rate of biotransformation
16. Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine
17. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin
18. Human UGT2B7 catalyzes morphine glucuronidation
19. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine