A short low-level exposure to metavanadate during a cell cycle-specific interval of time is sufficient to permanently derange the differentiative properties of Mel cells

Mutagenesis

Volumn 16, Issue 5, 2001, Pages 395-400

  Foresti, M ^a   Scippa, S ^a   Mele, F ^a   Palladino, G ^a   De Vincentiis, M ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ANTIMUTAGENIC AGENT; DNA; HYDROXYUREA; MUTAGENIC AGENT; THYMIDINE; TRITIUM; VANADIC ACID; VANILLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ERYTHROLEUKEMIA CELL; EXPOSURE; GENOME; INHERITANCE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROGENY; SOLUBILITY;

EID: 0034828298     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/16.5.395     Document Type: Article

References (33)

1. Genotoxic studies of vanadium pentoxide (V(2)O(5)) in male mice. II. Effects in several mouse tissues
2. Superoxide anion induced DNA strand-break metabolic pathway in human leukocites: Effects of vanadate
3. Vanadate is a potent (Na,K) ATPase inhibitor found in ATP derived from muscle
4. Hydroxyurea: Effects on deoxyribonucleotide pool sizes correlates with effects on DNA repair in mammalian cells
5. Biological effects of low-level exposure: A perspective from U.S. EPA scientists. Toxicologic defense mechanisms and the shape of dose-response relationships
6. Antitumour activity of vanadium compounds. Metal ions in biological systems
7. Vanadium stimulates the (Na+, K+) pump in Friend erythroleukemia cells and blocks erythropoiesis
8. Effect of bacitracin on erythroid differentiation of Mel cells
9. Inhibition of Mel cell's capacity to undergo erythroid differentiation by chemicals added during induction
10. Inhibition of erythroid differentiation in Mel cells. Cell cycle and DNA repair activity
11. Two periods of sensitivity to mutagens in induced cells with basically different outcomes
12. Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethylsulfoxide
13. Food and Drug Administration perspective of the inclusion of the effects of low-level exposures in safety and risk assessment
14. Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds
15. Dose-response and threshold-mediated mechanisms in mutagenesis: Statistical models and study design
16. Rec assay and mutagenicity studies on metal compounds
17. Antimutagenesis by factors affecting DNA repair in bacteria
18. Separation of vanadocytes: Determination and characterization of vanadium ions in the separated blood cells of the ascidian, Ascidia ahodori
19. Vanadium compounds as insulin mimics. Metal ions in biological systems
20. An assessment of the genotoxicity of vanadium
21. Genotoxicity of vanadium pentoxide evaluated by the single-cell gel electrophoresis assay in human lymphocytes
22. Different effects of vanadium ions on some DNA-metabolizing enzymes
23. Vanadium distribution in rats and DNA cleavage by vanadyl complex: Implication for vanadium toxicity and biological effects. Molecular mechanisms of metal toxicity and carcinogenicity
24. Detection of oxovanadium(IV) and characterization of its ligand environment in subcellular fractions of the liver of rats treated with pentavalent vanadium(V)
25. The synergistic effects of vanillin on recombination predominate over its antimutagenic action in relation to MMC-induced lesion in somatic cells of Drosophila melanogaster
26. Ultrastructure and X-ray microanalysis of blood cells of Ascidia malaca
27. X-ray microanalytical studies on cryofixed blood cells of the ascidian Phallusia mammillata. II. Elemental composition of the various blood cell types
28. Vanadium(IV)-mediated free radical generation and related 2′-deoxyguanosine hydroxylation and DNA damage
29. Modulation of DNA damage and DNA repair in chromatin
30. Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells
31. Inhibition of phosphate-metabolising enzymes by oxovanadium(V) complexes. Metal ions in biological systems
32. Transient inhibition of initiation of S-phase associated with induction of murine erythroleukemia cells to erythroid differentiation by dimethylsulfoxide