AM reverses pressor response to ET-1 independently of NO in rat coronary circulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 3 50-3, 2001, Pages

  Kinnunen, Pietari ^a   Piuhola, Jarkko ^a   Ruskoaho, Heikki ^a   Szokodi, István ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Coronary vasoconstriction; N nitro L arginine methyl ester; Perfused rat heart

Indexed keywords

ADRENOMEDULLIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; HEART PERFUSION; ISOLATED HEART; MALE; NONHUMAN; PERFUSION PRESSURE; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

EID: 0034828152     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.3.h1178     Document Type: Article

References (47)

1. Cloning and expression of a cDNA encoding an endothelin receptor
2. Calcitonin gene-related peptide is a potent vasodilator
3. Endothelin release during ischemia and reperfusion of isolated perfused rat hearts
4. Endothelin at pathophysiological concentrations mediates coronary vasoconstriction via the endothelin-A receptor
5. Hemodynamic, hormonal, and renal effects of adrenomedullin in conscious sheep
6. Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin
7. Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells
8. Adrenomedullin mediates vasodilation via CGRP 1 receptors
9. L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat
10. The discovery of endothelium-dependent relaxation
11. Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat
12. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells
13. Regulation of adrenomedullin production in rat endothelial cells
14. Adrenomedullin: Potential in physiology and pathophysiology
15. Autocrine role for the endothelth-B receptor in the secretion of adrenomedullin
16. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
17. Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells
18. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium
19. 2+-sensitivity in pig coronary arterial smooth muscle
20. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed
21. Inhibition of endothelium-derived relaxing factor enhances endothelin-mediated vasoconstriction
22. 1 receptor antagonists in vivo and in vitro
23. Enhanced endothelin-mediated coronary vasoconstriction and attenuated basal nitric oxide activity in experimental hypercholesterolemia
24. + channels and depolarizes smooth muscle cells of porcine coronary artery
25. Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells
26. Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats
27. Effect of endogenous nitric oxide on cardiac systolic and diastolic function during ischemia and reperfusion in the rat isolated perfused heart
28. Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology
29. ATP channels
30. Autocrine regulation of the endothelin- 1 gene in rat endothelial cells
31. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
32. Adrenomedullin and the control of fluid and electrolyte homeostasis
33. 2+ mobilization, in bovine aortic endothelial cells
34. Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature
35. Endothelial cells actively synthesize and secrete adrenomedullin
36. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-alpha
37. Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells
38. Inotropic effect of adrenomedullin in the isolated perfused rat heart
39. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide
40. Endothelin receptor is coupled to phospholipase C via a pertussis toxin- insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells
41. + channels
42. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo
43. Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase
44. Nitric oxide in the regulation of blood flow and arterial pressure
45. Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists
46. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
47. Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery