Age-related changes in the mitochondrial depolarization induced by oxidative injury in human peripheral blood leukocytes

Free Radical Research

Volumn 35, Issue 4, 2001, Pages 395-403

  Tsai, Kelvin ^a,b   Hsu, Tai Ger ^c   Lu, Fung Jou ^d   Hsu, Chen Fu ^a,b   Liu, Tsung Yun ^a,b   Kong, Chi Woon ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TAIPEI   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Aging; Cyclosporin; Immunity; Leukocytes; Mitochondria; Oxidants

Indexed keywords

CYCLOSPORIN A; FLUOROCHROME; OXIDIZING AGENT; PYRIDINE; TERT BUTYL HYDROPEROXIDE;

ADULT; AGE; AGED; AGING; ANTIOXIDANT ACTIVITY; ARTICLE; BIOENERGY; BLOOD DONOR; CELL LABELING; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; EXPOSURE; FEMALE; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOCOMPETENT CELL; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PEROXIDATION; SENESCENCE; VOLUNTEER;

EID: 0034827348     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300911     Document Type: Article

References (32)

1. Effect of age on human neutrophils function
2. Age-related defect in signal transduction during lectin activation of murine T lymphocytes
3. Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria
4. Mitochondria in organismal aging and degeneration
5. The rate of mitochondrial mutagenesis is faster in mice than humans
6. Dennett. Respiratory chain failure in adult muscle fibers: Relationship with ageing and possible implications for the neuronal pool
7. Mitochondrial dysfunction in lymphocytes from old mice: Enhanced activation of the permeability transition
8. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity, and oxidants increase
9. Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation
10. The mitochondrial permeability transition pore and its role in cell death
11. The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites
12. Effects in vitro of several antioxidants on the natural killer function of aging mice
13. The free radical hypothesis of aging: An appraisal of the current status
14. Methodological considerations for implementation of lymphocyte subset analysis in a clinical reference laboratory
15. Functional heterogeneity of an isolated mitochondrial population revealed by cytofluorometric analysis at the single organelle level
16. Mitochondrial dysfunction in lymphocytes from old mice, enhanced activation of the permeability transition
17. 10 N-Nonyl-acridine orange: A fluorescent probe which stains mitochondria independently of their energetic state
18. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants, comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5 (and 6)-carboxy-2′7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
19. Fluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation
20. Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides
21. Flow cytometry principles for clinical laboratory practice
22. Age-related changes in the peroxyl radical scavenging capacity of human plasma
23. Improvement by several antioxidants of macrophage function in vitro
24. Increased uptake and retention of rhodamine 123 by mitochondria of old human fibroblasts
25. Human epidermal cells progressively lose their cardiolipins during ageing without change in mitochondrial transmembrane potential
26. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide
27. tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids
28. Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
29. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidylprolyl cis-trans isomerase and preventing interacting with the adenine nucleotide translocase
30. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
31. Mitochondrial disease in mouse results in increased oxidative stress
32. 2+-induced mitochondrial membrane permeabilization: Role of coenzyme Q redox state