Genetic polymorphisms in the androgen receptor and type II 5α-reductase genes in prostate enlargement

Journal of Urology

Volumn 166, Issue 4, 2001, Pages 1560-1564

  Shibata, Atsuko ^a   Stamey, Thomas A ^a   McNeal, John E ^a   Cheng, Iona ^a   Peehl, Donna M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Androgen; Polymorphism (genetics); Prostate; Prostatic hyperplasia; Receptors

Indexed keywords

ANDROGEN RECEPTOR; DNA FRAGMENT; STEROID 5ALPHA REDUCTASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROSTATECTOMY; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRINUCLEOTIDE REPEAT;

EID: 0034827156     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65830-2     Document Type: Article

References (30)

1. Benign prostatic hyperplasia: Antecedents and natural history
2. Origin and evolution of benign prostatic enlargement
3. Origins, distribution, and risk of benign prostatic hypertrophy
4. 5 Alpha-reductase in prostate disease
5. Molecular control of prostate growth
6. Androgen metabolism and prostate cancer: Establishing a model of genetic susceptibility
7. Genetic predisposition to prostate cancer: Possible explanations for ethnic differences in risk
8. The CAG repeat within the androgen receptor gene and benign prostatic hyperplasia
9. CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U. S. physicians
10. Androgen receptor CAG repeat length polymorphism in benign prostatic hyperplasia (BPH): Correlation with adenoma growth
11. Morphometric and clinical studies on 68 consecutive radical prostatectomies
12. Biological determinants of cancer progression in men with prostate cancer
13. Polymorphisms in the androgen receptor and type II 5α-reductase genes and prostate cancer prognosis
14. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
15. Clonal analysis of bilateral breast cancer
16. Molecular genetics of steroid 5 alpha-reductase 2 deficiency
17. Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme
18. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
19. Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: Possible pathogenetic relevance for the (CAG)n-expanded neuronopathies
20. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility
21. Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length
22. Polymorphisms in the vitamin D receptor gene and the androgen receptor gene and the risk of benign prostatic hyperplasia
23. A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase
24. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
25. Accuracy in preoperative estimation of prostatic size. A comparative evaluation of rectal palpation, intravenous pyelography, urethral closure pressure profile recording and cystourethroscopy
26. The development of human benign prostatic hyperplasia with age
27. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor
28. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer