Androgen receptor CAG repeat length polymorphism in benign prostatic hyperplasia (BPH): Correlation with adenoma growth

Prostate

Volumn 41, Issue 4, 1999, Pages 253-257

  Mitsumori, Kenji ^a   Terai, Akito ^a   Oka, Hiroya ^a   Segawa, Takehiko ^a   Ogura, Keiji ^a   Yoshida, Osamu ^a   Ogawa, Osamu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Adenoma size; Androgen receptor; Benign prostatic hyperplasia; CAG microsatellite; Relative risk

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GLUTAMINE; MICROSATELLITE DNA;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; GENE EXPRESSION REGULATION; GENETIC RISK; HORMONE RESISTANCE; HUMAN; HUMAN CELL; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROSTATE ADENOMA; PROSTATE HYPERTROPHY; TUMOR GROWTH; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; CELL DIVISION; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROSTATIC HYPERPLASIA; RECEPTORS, ANDROGEN; REGRESSION ANALYSIS; RISK; TRINUCLEOTIDE REPEATS;

EID: 0032709766     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19991201)41:4<253::AID-PROS5>3.0.CO;2-9     Document Type: Article

References (18)

1. Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984;132: 474-479.
2. McConnell JD. Prostatic growth: new insights into hormonal regulation. Br J Urol 1995;76(Suppl 1):5-10.
3. Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992;12:241-253.
4. Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994;22:3181-3186.
5. n-expanded neuronopathies. Hum Mol Genet 1995;4:523-527.
6. Choong CS, Kemppainen JA, Zhou Z-X, Wilson EM. Reduced androgen receptor gene expression with first exon CAG repeat expansion. Mol Endocrinol 1996;10:1527-1535.
7. Biancalana V, Serville F, Pommier J, Julien J, Hanauer A, Mandel JL. Moderate instability of the trinucleotide repeat in spino bulbar muscular atrophy. Hum Mol Genet 1992;1:255-258.
8. Coetzee GA, Ross RK. Re: prostate cancer and the androgen receptor. J Natl Cancer Inst 1994;86:872-873.
9. Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH, Kantoff PW. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997;94:3320-3323.
10. Hardy DO, Scher HI, Bogenreider T, Sabbatini P, Zhang ZF, Nanus DM, Catterall JF. Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab 1996;81:4400-4405.
11. Irvine RA, Yu MC, Ross RK, Coetzee GA. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995;55: 1937-1940.
12. Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res 1997;57:1194-1198.
13. Ingles SA, Ross RK, Yu MC, Irvine RA, La Pera G, Haile RW, Coetzee GA. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst 1997;89:166-170.
14. Hakimi JM, Schoenberg MP, Rondinelli RH, Piantadosi S, Barrack ER. Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer. Clin Cancer Res 1997;3:1599-1608.
15. Giovannucci E, Platz EA, Stampfer MJ, Chan A, Krithivas K, Kawachi I, Willett WC, Kantoff PW. The CAG repeat within the androgen receptor gene and benign prostatic hyperplasia. Urology 1999;53:121-125.
16. Kitagawa N, Ichikawa T, Akimoto S, Shimazaki J. Natural course of human benign prostatic hyperplasia with relation to urinary disturbance. Prostate 1994;24:279-284.
17. Partin AW, Page WF, Lee BR, Sanda MG, Miller RN, Walsh PC. Concordance rates for benign prostatic disease among twins suggest hereditary influence. Urology 1994;44:646-650.
18. Sanda MG, Beaty TH, Stutzman RE, Childs B, Walsh PC. Genetic susceptibility of benign prostatic hyperplasia. J Urol 1994; 152:115-119.