Strategy for modulation of central dopamine transmission based on the partial agonist concept in schizophrenia therapy

Japanese Journal of Pharmacology

Volumn 86, Issue 4, 2001, Pages 376-380

  Inoue, A ^a   Nakata, Y ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Affinity; Antipsychotic; Dopamine receptor; Intrinsic efficacy; Partial agonist; Schizophrenia

Indexed keywords

7 [3 [4 (2,3 DIMETHYLPHENYL) 1 PIPERAZINYL]PROPOXY] 2(1H) QUINOLINONE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ARIPIPRAZOLE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE AUTORECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; OXIDOPAMINE; PARTIAL AGONIST; PRAMIPEXOLE; PRECLAMOL; PROPYLNORAPOMORPHINE; ROXINDOLE; SPIPERONE; TALIPEXOLE;

ATTENTION DEFICIT DISORDER; BINDING AFFINITY; BRAIN DYSFUNCTION; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DRUG BINDING; DRUG CLASSIFICATION; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; ENDOCRINE DISEASE; EXTRAPYRAMIDAL SYMPTOM; GILLES DE LA TOURETTE SYNDROME; HUMAN; HYPOPHYSIS TUMOR; NONHUMAN; PARKINSON DISEASE; PATHOLOGY; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SCHIZOPHRENIA; SECOND MESSENGER; SYMPTOM;

EID: 0034826997     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.86.376     Document Type: Review

References (26)

1. Antipsychotic drug doses and neuroleptic/dopamine receptors
2. Clozapine for the treatment-resistant schizophrenic
3. Neuroleptic-induced deficit syndrome (NIDS)
4. The effect of L-dopa on young patients with simple schizophrenia treated with neuroleptic drugs
5. Responses to apomorphine, amphetamine and neuroleptics in schizophrenic subjects
6. 4 receptor with high affinity for the antipsychotic clozapine
7. The cerebral cortex: A case for a common site of action of antipsychotics
8. Role of serotonin in the action of atypical antipsychotic drugs
9. Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs
10. Structure of dopamine receptors
11. Structure and function of dopamine receptors
12. 2 dopamine receptor isoforms
13. 2 dopamine receptors produced by alternative RNA splicing
14. 3) as a target for neuroleptics
15. On the mechanism of neuroleptic induced increase in striatal dopamine release: Brain dialysis provides direct evidence for mediation by autoreceptor localized on nerve terminals
16. 3 receptor mutant mice
17. 2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum
18. Dopamine agonists in schizophrenia
19. Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats
20. Dopamine agonist treatment of schizophrenia with n-propyl-norapomorphine
21. Partial agonists, full agonists, antagonists: Dilemmas of definition
22. Absence of receptor reserve at striatal dopamine receptors regulating cholinergic neuronal activity
23. Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes
24. 2 receptor following repeated treatment in the rat striatum
25. 2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary
26. Effects of the novel antipsychotic agent 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy}-3,4-dihydro-2(1H)-quinolino ne (OPC-14597) on prolactin release from the rat anterior pituitary gland