Aripiprazole, a novel antipsychotic drug, inhibits quinpirole-evoked GTPase activity but does not up-regulate dopamine D2 receptor following repeated treatment in the rat striatum

European Journal of Pharmacology

Volumn 321, Issue 1, 1997, Pages 105-111

  Inoue, Atsuko ^a   Miki, Sinya ^a   Seto, Mayumi ^a   Kikuchi, Tetsuro ^b   Morita, Seiji ^b   Ueda, Hiroshi ^c,d   Misu, Yoshimi ^c   Nakata, Yoshihiro ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

Author keywords

Antipsychotic drug; Aripiprazole; Dopamine receptor; Ribonuclease protection assay; Striatum, rat

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ARIPIPRAZOLE; DOPAMINE 2 RECEPTOR; GUANOSINE TRIPHOSPHATASE; HALOPERIDOL; NEUROLEPTIC AGENT; QUINPIROLE; RIBONUCLEASE; SPIPERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; BINDING, COMPETITIVE; DOPAMINE AGONISTS; GTP PHOSPHOHYDROLASES; HALOPERIDOL; MALE; MEMBRANES; NEOSTRIATUM; OLIGONUCLEOTIDES, ANTISENSE; PIPERAZINES; QUINOLONES; QUINPIROLE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RNA, MESSENGER; UP-REGULATION;

EID: 0031577960     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00920-X     Document Type: Article

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