Characterization of a new brain-specific isoform of the EWS oncoprotein

European Journal of Biochemistry

Volumn 268, Issue 12, 2001, Pages 3483-3489

  Melot, Thomas ^a   Dauphinot, Luce ^a   Sévenet, Nicolas ^a   Radvanyi, François ^b   Delattre, Olivier ^a,c  

^a INSERM   (France)

^b INSTITUT CURIE   (France)

^c INSTITUT CURIE   (France)

Author keywords

Brain; Ewing; EWS; Isoform

Indexed keywords

ISOPROTEIN; NERVE GROWTH FACTOR; ONCOPROTEIN; PROTEIN FUS; PROTEIN TAFII68; PROTEIN TLS; RNA BINDING PROTEIN EWS; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EXON; HUMAN; MOUSE; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA BINDING; RNA SPLICING; RNA TRANSCRIPTION;

MURINAE;

EID: 0034823778     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02251.x     Document Type: Article

References (48)

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2. Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union
3. EWS and ATF-1 gene fusion induced by t(12; 22) translocation in malignant melanoma of soft parts
4. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor
5. Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation
6. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma
7. Fusion of the EWS and CHOP genes in myxoid liposarcoma
8. A novel zinc finger gene is fused to EWS in small round cell tumor
9. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
10. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
11. The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly
12. The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator
13. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein
14. EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene
15. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
16. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
17. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
18. Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17) (q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma
19. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP
20. A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene
21. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins
22. The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription
23. Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II
24. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: Interactions between two members of the TET family. EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes
25. Human POMp75 is identified as the pro-oncoprotein TLS/FUS: Both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation
26. Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation
27. Male sterility and enhanced radiation sensitivity in TLS (-/-) mice
28. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
29. Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS
30. The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS
31. The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain
32. Production and characterization of mouse monoclonal antibodies to wild-type and oncogenic FLI-1 proteins
33. hTAF (II), 68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
34. Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation
35. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains
36. Complete sequence of the bithorax complex of Drosophila
37. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member
38. Versican V2 is a major extracellular matrix component of the mature bovine brain
39. The Listeria monocytogenes gene ctpA encodes a putative P-type ATPase involved in copper transport
40. Brain derived versican V2 is a potent inhibitor of axonal growth
41. Combinatorial control of a neuron-specific exon
42. Essential nucleotides direct neuron-specific splicing of gamma 2 pre-mRNA
43. A unique intronic splicing enhancer controls the inclusion of the agrin Y exon
44. Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo
45. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart
46. Alternative pre-mRNA splicing: The logic of combinatorial control
47. Splicing regulation in neurons: Tinkering with cell-specific control
48. Alternatively spliced forms of nerve- and muscle-derived agrin: Their roles at the neuromuscular junction