Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes

AIDS Research and Human Retroviruses

Volumn 17, Issue 11, 2001, Pages 1063-1066

  Kelleher, A D ^a   Booth, Jr ^a   Sewell, A K ^a   Oxenius, A ^a   Cerundolo, V ^a   McMichael, A J ^a   Phillips, R E ^a   Price, D A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ASPARTIC PROTEINASE; CD8 ANTIGEN; GAG PROTEIN; GAMMA INTERFERON; HLA A2 ANTIGEN; ISOLEUCYLLEUCYLLYSYLGLUTAMYLPROLYLVALYLHISTIDYLGLYCYLVALINE; LACTACYSTIN; LYSYLARGINYLTRYPTOPHYLISOLEUCYLISOLEUCYLMETHIONYLGLYCYLLEUCYLASPARAGINYLLYS INE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDASE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE; SERYLLEUCYLTYROSYLASPARAGINYLTHREONYLVALYLALANYLTHREONYLLEUCINE; THREONINE; UNCLASSIFIED DRUG; VALYLISOLEUCYLTYROSYLGLUTAMINYLTYROSYLMETHIONYLASPARTYLASPARTYLLEUCINE;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIVIRAL ACTIVITY; ARTICLE; BETA CHAIN; CARBOXY TERMINAL SEQUENCE; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; DRUG EFFICACY; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; VIRUS REPLICATION;

ADENOSINE TRIPHOSPHATASES; ANTIGEN PRESENTATION; CYSTEINE ENDOPEPTIDASES; EPITOPES; GENES, MHC CLASS I; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MULTIENZYME COMPLEXES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RITONAVIR; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034821167     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922201300343744     Document Type: Article

References (12)

1. Rational design of peptide-based HIV proteinase inhibitors
2. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
3. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
4. An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses
5. How an inhibitor of the HIV-1 protease modulates proteasome activity
6. Crystal structure of the 20S proteasome from Archaeon T. acidophilum at 3.4Å resolution
7. A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
8. Purification and characterization of a multicatalytic high molecular mass proteinase from rat skeletal muscle
9. IFN-γ exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase
10. Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the α2 domain
11. Kinetics of antiviral activity and intracellular pharmacokinetics of human immunodeficiency virus type 1 protease inhibitors in tissue culture
12. Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans