Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: Comparison of antibody to CD11a with cyclosporin a and clobetasol propionate

Laboratory Investigation

Volumn 81, Issue 9, 2001, Pages 1253-1261

  Zeigler, Mary ^a   Chi, Yiqing ^a   Tumas, Daniel B ^b   Bodary, Sarah ^b   Tang, Haicheng ^a   Varani, James ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOBETASOL PROPIONATE; CYCLOSPORIN A; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; HUMAN; IMMUNOHISTOLOGY; MORPHOMETRICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS; SCID MOUSE; SKIN TRANSPLANTATION; SKINFOLD THICKNESS; T LYMPHOCYTE;

EID: 0034817252     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780339     Document Type: Article

References (50)

1. A contact dermatitis reaction to clobetasol propionate cream associated with resolution of recalcitrant, generalized granuloma annulare
2. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interelukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias also measured in circulating blood T cells in psoriasis patients
3. Is epidermal proliferation in psoriatic skin grafts on nude mice driven by T-cell derived cytokines?
4. Cyclosporin nephrotoxicity: Implications for dermatology
5. Psoriasiform architecture of murine epidermis overlaying human psoriatic dermis transplanted to SCID mice
6. Organ culture of normal and psoriatic skin
7. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
8. Treatment of murine lupus with monoclonal antibodies to LFA-1
9. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon-γ and is mediated by intercellular adhesion molecule-1
10. Overexpression of transforming growth factor-α in psoriatic epidermis
11. Psoriasis
12. Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3
13. T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice
14. The C-X-C chemokine Mig is highly expressed in the papillae of psoriatic lesions
15. Detection of transforming growth factor-α in normal, malignant, and hyperproliferative human keratinocytes
16. Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis
17. Recovery of human skin collagen synthesis after short-term topical corticosteroid treatment and comparison between young and old subjects
18. Statistical methods in animal improvement: Historical overview
19. The human lymphocyte function-associated (HLFA) antigen and a related macrophage differentiation antigen (Hmac-1): Functional effects of subunit-specific monoclonal antibodies
20. Cyclosporin A down-regulates LTA4 hydrolase level in human keratinocyte cultures
21. Tacrolimus (FK506): A new therapeutic agent for recalcitrant psoriasis
22. The effects of cyclosporin A and FK506 on proliferation and IL-8 production of cultured human keratinocytes
23. FK506 and cyclosporin A inhibit growth factor-stimulated keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle
24. Maintenance of epidermal structure of psoriatic skin in organ culture
25. Organ culture of psoriatic skin: Effect of TGF-α and TGF-β on epidermal structure in vitro
26. Long-term maintenance of psoriatic human skin on congenitally athymic (nude) mice
27. Psoriasis
28. Involved and uninvolved skin from psoriatic subjects: Are they equally diseased? Assessment by skin transplantation to congenitally athymic (nude) mice
29. Duration of improvement in psoriasis after treatment with tazarotene plus clobetasol propionate: Comparison of maintenance treatments
30. Angiogenic properties of normal and psoriatic skin associate with epidermis, not dermis
31. Comparative analysis of normal and psoriatic skin both in vivo and in vitro
32. Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-SCID mouse allograft model is T cell mediated and inhibited by a combination of cyclosporin and rapamycin
33. Potent and effective prolongation by anti-LFA-1 monoclonal antibody monotherapy of non-primarily vascularized heart allograft survival in mice without T cell depletion
34. The cytokine network in psoriasis
35. Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model
36. Decreased growth inhibition by recombinant gamma interferon is associated with increased production of transforming growth factor alpha in keratinocytes cultured from psoriatic lesions
37. Injection of prepsoriatic skin with CD4+ T cells induces psoriasis
38. Expression, topography and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin
39. Proliferation and glycosaminoglycan secretion in fibroblasts from psoriatic skin: Differential response to retinoids
40. Epithelialization
41. Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses
42. Effects of cyclosporin and ultraviolet radiation on growth and ornithine decarboxylase activity in cultured epidermal keratinocytes
43. Psoriasis: A T-cell mediated autoimmune disease mediated by streptococcal superantigen?
44. Human psoriatic skin in organ culture: Comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor
45. All-trans retinoic acid stimulates events in organ-cultured skin that underlie repair
46. Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice
47. Cyclosporin A inhibits keratinocyte cytokine gene expression
48. The mechanisms of action of cyclosporin A in the treatment of psoriasis
49. Dermal injection of immunocytes induces psoriasis