Simultaneous modeling of pharmacokinetics and pharmacodynamics of propafenone in healthy subjects

Acta Pharmacologica Sinica

Volumn 22, Issue 10, 2001, Pages 956-960

  Cai, W M ^a   Zhang, Y D ^a   Chen, B ^a   Cai, M H ^a   Luo, J P ^a   Ling, S S ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cytochrome P 450 CYP2D6; Models; Pharmacokinetics; Propafenone

Indexed keywords

CYTOCHROME P450 2D6; PROPAFENONE; CYTOCHROME P 450 CYP2D6;

AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG METABOLISM; ELECTROCARDIOGRAM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEASUREMENT; NORMAL HUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ADULT; BLOOD; GENETIC POLYMORPHISM; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHENOTYPE;

ADULT; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; FEMALE; HUMAN; MALE; PHENOTYPE; POLYMORPHISM (GENETICS); PROPAFENONE;

EID: 0034815924     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Clinical pharmacokinetics of propafenone
2. CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects
3. Pharmacodynamics
4. Dextromethorphan metabolic phenotyping in a Chinese population
5. Determination of propafenone enantiomeric concentrations I human plasma by stereoselective high performance liquid chromatography
6. Simultaneous modeling of pharmacokinetics and pharmacodynamica of metoprolol in normotensive spontaneously hypertensive rats
7. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
8. Pharmacokinetic-pharmacodynamic modeling of metoprolol stereoisomers in spontaneously hypertensive rat