Human liver disease decreases methacrylyl-CoA hydratase and β-hydroxyisobutyryl-CoA hydrolase activities in valine catabolism

Clinica Chimica Acta

Volumn 312, Issue 1-2, 2001, Pages 115-121

  Ishigure, Kiyoshi ^a   Shimomura, Yoshiharu ^b   Murakami, Taro ^b   Kaneko, Tetsuya ^a   Takeda, Shin ^a   Inoue, Sohichiro ^a   Nomoto, Shuji ^a   Koshikawa, Katsumi ^a   Nonami, Toshiaki ^a   Nakao, Akimasa ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Hydroxyisobutyryl CoA hydrolase; Cirrhosis; Hepatocellular carcinoma; Human liver; Methacrylyl CoA hydratase; Valine catabolism

Indexed keywords

BETA HYDROXYISOBUTYRYL COENZYME A HYDROLASE; ENOYL COENZYME A HYDRATASE; HYDROLASE; MESSENGER RNA; UNCLASSIFIED DRUG; VALINE;

ADULT; AGED; ARTICLE; CATABOLISM; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FUNCTION; LIVER INJURY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

AGED; CARCINOMA, HEPATOCELLULAR; ENOYL-COA HYDRATASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATITIS; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER DISEASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; REFERENCE VALUES; THIOLESTER HYDROLASES; VALINE;

EID: 0034813742     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(01)00597-6     Document Type: Article

References (16)

1. Branched-chain amino acid metabolism
2. Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver
3. Embryonic-fetal toxicity and teratogenic effects of a group of methacrylate esters in rats
4. Genotoxicity in mouse lymphoma cells of chemicals capable of Michael addition
5. The conjugation of glutathione with unsaturated acyl thiol esters and the metabolic formation of S-carboxyalkylcysteines
6. beta-Hydroxyisobutyryl coenzyme A deacylase deficiency: A defect in valine metabolism associated with physical malformations
7. The valine catabolic pathway in human liver: Effect of cirrhosis on enzyme activities
8. Activation of branched-chain alpha-keto acid dehydrogenase complex by exercise: Effect of high-fat diet intake
9. Citrate synthase from rat liver
10. Quantitative hepatitis C RNA-polymerase chain reaction and detection with DNA-ELISA
11. A molecular model of human branched-chain amino acid metabolism
12. Regulation of valine catabolism in canine tissues: Tissue distributions of branched-chain aminotransferase and 2-oxo acid dehydrogenase complex, methacrylyl-CoA hydratase and 3-hydroxyisobutyryl-CoA hydrolase
13. Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase
14. Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex
15. Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria