Rat pancreatic acinar cells express a cytosolic phospholipase d1b isoform that is not regulated by cholecystokinin

Pflugers Archiv European Journal of Physiology

Volumn 442, Issue 6, 2001, Pages 910-919

  Bosch, R R ^a   Harris, A B ^b   Van Emst de Vries, S E ^a   Pont, J J H H M D ^a   Willems, P H G M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

Chinese hamster ovary cells; Cholecystokinin A receptor; Phorbol ester; Phospholipase C; Phospholipase D; Protein kinase C; Rat pancreatic acini; Thapsigargin

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; PHORBOL ESTER; PHOSPHOLIPASE C; PHOSPHOLIPASE D1; PHOSPHOLIPASE D1 B; PROTEIN KINASE C; THAPSIGARGIN; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL ISOLATION; CHO CELL; CONTROLLED STUDY; CYTOSOL; ENZYME ANALYSIS; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL FRACTIONATION; CHO CELLS; CHOLECYSTOKININ; CRICETINAE; CYTOSOL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); ISOENZYMES; PANCREAS; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE D; PROTEIN KINASE C; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SINCALIDE; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN; TRITIUM;

EID: 0034813358     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240100611     Document Type: Article

References (57)

1. Stimulus-secretion coupling in pancreatic acinar cells
2. Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini
3. Pancreatic amylase secretion and cytoplasmic free calcium: Effects of ionomycin, phorbol dibutyrate and diacylglycerols alone and in combination
4. 1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion
5. Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: Phosphorylation-dependent changes in potency and efficacy
6. Downregulation of protein kinase C in guinea pig pancreatic acini: Effects on secretion
7. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
8. Multiple sources of 1,2-diacylglycerol in isolated rat pancreatic acini stimulated by cholecystokinin. Involvement of phosphatidylinositol bisphosphate and phosphatidylcholine hydrolysis
9. 2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini
10. Diradyl-glycerol formation in cholecystokinin-stimulated rabbit pancreatic acini. Assessment of precursor phospholipids by means of molecular species analysis
11. Inositol trisphosphate and calcium signalling
12. Phosphatidylcholine breakdown and signal transduction
13. Involvement of phospholipase D in caerulein-induced phosphatidylcholine hydrolysis in rat pancreatic acini
14. Pancreas growth, tyrosine kinase, PtdIns 3-kinase, and PLD involve high-affinity CCK-receptor occupation
15. Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini
16. The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D
17. 2+-calmodulin-dependent pathway in isolated rat pancreatic acini
18. Phorbol ester stimulates the hydrolysis of phosphatidylethanolamine in leukemic HL-60, NIH 3T3 and baby hamster kidney cells
19. Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding
20. Potentiating role of cyclic AMP in pancreatic enzyme secretion, demonstrated by means of forskolin
21. U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells
22. 2+ and protein kinase C in receptor-mediated phospholipase D activation in Chinese hamster ovary cells expressing the cholecystokinin-A receptor
23. A rapid method of total lipid extraction and purification
24. Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA
25. Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver
26. Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
27. 2+ mobilization is paralleled by down-regulation of protein kinase C-α in CHO cells expressing the CCK-A receptor
28. Expression and regulation of phospholipase D in the human keratinocyte cell line HaCaT
29. Regulation of phospholipase D
30. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps
31. The inositol phosphate-calcium signaling system in nonexcitable cells
32. Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5′-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol
33. Possible role of phospholipase D in cellular differentiation and apoptosis
34. Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase Cα
35. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2
36. Differential expression of human phospholipase D genes
37. Characterization of human PLD2 and the analysis of PLD isoform splice variants
38. Mammalian phospholipase D structure and regulation
39. Rat brain membrane-bound phospholipase D
40. Phospholipase D activity in L1210 cells: A model for oleate-activated phospholipase D in intact mammalian cells
41. Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain
42. Inhibition of phospholipase D by a protein factor from bovine brain cytosol. Partial purification and characterization of the inhibition mechanism
43. Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation
44. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
45. Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D
46. Arf and RhoA regulate both cytosolic and membrane-bound phospholipase D from human placenta
47. Identification of Rab5 but not Rab3A in rat pancreatic zymogen granule membranes
48. Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini
49. 2, phospholipase D, and protein kinase C
50. Regulation of diacylglycerol levels in carbachol-stimulated pancreatic acinar cells: Relationship to the breakdown of phosphatidylcholine and metabolism to phosphatidic acid
51. Phorbol ester activation of phospholipase D in human monocytes but not peripheral blood lymphocytes
52. Effects of phorbol ester on phospholipase D and mitogen-activated protein kinase activities in T-lymphocyte cell lines
53. Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells: Possible involvement of calcium/calmodulin
54. Augmentation by calmodulin of ADP-ribosylation factor-stimulated phospholipase D activity in permeabilized rabbit peritoneal neutrophils
55. Mechanism of phospholipase D activation induced by extracellular ATP in osteoblast-like cells
56. Regulation of phospholipase D activity in synaptosomes permeabilized with Staphylococcus aureus alpha-toxin
57. Calmodulin-binding proteins and calmodulin-regulated enzymes in dog pancreas