U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells

European Journal of Pharmacology

Volumn 346, Issue 2-3, 1998, Pages 345-351

  Bosch, Remko R ^a   Patel, Anjana M P ^b   Van Emst De Vries, Sjenet E ^a   Smeets, Rolf L L ^a   De Pont, Jan Joep H H M ^a   Willems, Peter H G M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

CCK(A) receptor; Phospholipase C; Phospholipase D; Protein kinase C; U73122; U73343

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; CALCIUM; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; DIACYLGLYCEROL; DIMETHYL SULFOXIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; MYRISTIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHODIESTERASE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C; STEROID; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRENES; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PHOSPHOLIPIDS; PYRROLIDINONES; RECEPTORS, CHOLECYSTOKININ; SPECTROMETRY, FLUORESCENCE;

EID: 0032502626     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00070-3     Document Type: Article

References (25)

1. Babich M., Alford G.E., Nissenson R.A. A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signalling pathways in rat osteosarcoma cells. J. Pharmacol. Exp. Ther. 269:1994;172-177.
2. Bleasdale J.E., Thakur N.R., Gremban R.S., Bundy G.L., Fitzpatrick F.A., Smith R.J., Bunting S. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255:1990;756-768.
3. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
4. 2+ uptake and release properties of rat liver microsomes. Eur. J. Biochem. 234:1995;626-631.
5. Exton J.H. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta. 1212:1994;26-42.
6. Exton J.H. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur. J. Biochem. 243:1997;10-20.
7. Freeman E.J., Chisolm G.M., Tallant E.A. Role of calcium and protein kinase C in the activation of phospholipase D by angiotensin II in vascular smooth muscle cells. Arch. Biochem. Biophys. 319:1995;84-92.
8. 3. Biochem. J. 317:1996;403-409.
9. Lytton J., Westlin M., Hanley M.R. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266:1991;17067-17071.
10. Martin K.J., McConkey C.L., Jacob A.K., Gonzalez E.A., Khan M., Baldassare J.J. Effect of U-73122, an inhibitor of phospholipase C, on actions of parathyroid hormone in opossum kidney cells. Am. J. Physiol. 266:1994;F254-F258.
11. 2+ release and directly activates ion channels in mouse pancreatic acinar cells. Biochem. J. 324:1997;645-651.
12. Natarajan V., Scribner W.M., Vepa S. Regulation of phospholipase D by tyrosine kinases. Chem. Phys. Lipids. 80:1996;103-116.
13. Ohguchi K., Banno Y., Nakashima S., Nozawa Y. Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA. J. Biol. Chem. 271:1996;4366-4372.
14. Raymond J.R. Multiple mechanisms of receptor-G protein signalling specificity. Am. J. Physiol. 269:1995;F141-F158.
15. 2+ mobilization is paralleled by down-regulation of protein kinase C-α in CHO cells expressing the CCK-A receptor. Cell Calcium. 20:1996;1-9.
16. B receptors. Br. J. Pharmacol., in press.
17. Smith R.J., Sam L.M., Justen J.M., Bundy G.L., Bala G.A., Bleasdale J.E. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J. Pharmacol. Exp. Ther. 253:1990;688-697.
18. 2α-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production. Biochem. J. 298:1994;479-484.
19. Takai Y., Kikkawa U., Kaibuchi K., Nishizuka Y. Membrane phospholipid metabolism and signal transduction for protein phosphorylation. Adv. Cycl. Nucleotide Protein Phosphate Res. 18:1984;119-158.
20. Wank S.A. Cholecystokinin receptors. Am. J. Physiol. 269:1995;G628-G646.
21. 2+ stores in rabbit pancreatic acinar cells. Pflüg. Arch. 427:1994;233-243.
22. Wu H., James-Kracke M.R., Halenda S.P. Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated erythroleukemia cells. Biochemistry. 31:1992;3370-3377.
23. 2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J. Biol. Chem. 267:1992;13830-13835.
24. Yule D.I., Tseng M.-J., Williams J.A., Logsdon C.D. A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists. Am. J. Physiol. 265:1993;G999-G1004.
25. Zheng L., Stojilkovic S.S., Hunyady L., Krsmanovic L.Z., Catt K.J. Sequential activation of phospholipase-C and -D in agonist-stimulated gonadotrophs. Endocrinology. 134:1994;1446-1454.